Results 1 to 10 of about 1,488,373 (296)
Inferring binding energies from selected binding sites. [PDF]
PLoS Computational Biology, 2009 We employ a biophysical model that accounts for the non-linear relationship between binding energy and the statistics of selected binding sites. The model includes the chemical potential of the transcription factor, non-specific binding affinity of the ...
Yue Zhao, David Granas, Gary D Stormo
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p53 binding sites in transposons [PDF]
Frontiers in Genetics, 2012 Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Tomasz eZemojtel, Martin eVingron
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Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation [PDF]
PeerJ, 2021 GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and ...
Ashley Ryan Vidad +2 more
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Frontiers in Bioengineering and Biotechnology, 2022 Albumin-based cryogels for capturing haemin were synthesised by crosslinking different biomolecules, bovine serum albumin (BSA) and ovalbumin (OVA). The impact of the protein and coupling agent concentrations on cryogel’s mechanical properties, swelling ...
Solmaz Hajizadeh +2 more
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Pharmaceuticals, 2021 Treatment of neuroendocrine tumours with the radiolabelled somatostatin receptor subtype 2 (SST2) peptide agonist [177Lu]Lu-DOTA-TATE is effective and well-established.
Rosalba Mansi +3 more
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Binding sites analyser (BiSA): software for genomic binding sites archiving and overlap analysis. [PDF]
PLoS ONE, 2014 Genome-wide mapping of transcription factor binding and histone modification reveals complex patterns of interactions. Identifying overlaps in binding patterns by different factors is a major objective of genomic studies, but existing methods to archive ...
Matloob Khushi +3 more
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Surfaces, 2020 Surface density of adsorption sites on an adsorbent (including affinity-based sensors) is one of the basic input parameters in modeling of process kinetics in adsorption based devices.
Olga Jakšić +3 more
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Toxins, 2021 Cobra venoms contain three-finger toxins (TFT) including α-neurotoxins efficiently binding nicotinic acetylcholine receptors (nAChRs). As shown recently, several TFTs block GABAA receptors (GABAARs) with different efficacy, an important role of the TFTs ...
Lina Son +7 more
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Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2
Computational and Structural Biotechnology Journal, 2014 We have shown earlier that Kir2 channels are suppressed by the elevation of membrane cholesterol. Moreover, it is also well known that activation of Kir channels is critically dependent on a regulatory phospholipid, phosphatidylinositol-4,5-bisphosphate (
Avia Rosenhouse-Dantsker +2 more
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Crystal engineering of porous coordination networks for C3 hydrocarbon separation
SmartMat, 2021 C3 hydrocarbons (HCs), especially propylene and propane, are high‐volume products of the chemical industry as they are utilized for the production of fuels, polymers, and chemical commodities.
Mei‐Yan Gao +3 more
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