Results 1 to 10 of about 2,390,591 (254)
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +10 more sources
Targeting determinants of dosage compensation in Drosophila [PDF]
, 2006 The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Gregor D Gilfillan +5 more
core +13 more sources
Galactoside-Binding Site in LacY [PDF]
Biochemistry, 2014 Although an X-ray crystal structure of lactose permease (LacY) has been presented with bound galactopyranoside, neither the sugar nor the residues ligating the sugar can be identified with precision at ~3.5 Å. Therefore, additional evidence is important for identifying side chains likely to be involved in binding.
Jiang, Xiaoxu +4 more
openaire +6 more sources
Computing the protein binding sites [PDF]
BMC Bioinformatics, 2011 Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions.
Lusheng Wang, Fei Guo, Fei Guo
openaire +4 more sources
P53 Binding Sites in Transposons [PDF]
Frontiers in Genetics, 2012 Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Zemojtel, T., Vingron, M.
openaire +5 more sources
Being a binding site: Characterizing residue composition of binding sites on proteins [PDF]
Bioinformation, 2007 The Protein Data Bank contains the description of more than 45,000 three-dimensional protein and nucleic-acid structures today. Started to exist as the computer-readable depository of crystallographic data complementing printed articles, the proper interpretation of the content of the individual files in the PDB still frequently needs the detailed ...
Ivan, G, Szabadka, Z, Grolmusz, V
openaire +3 more sources
Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression [PDF]
, 2017 Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production.
Lengyel, Iván M., Morelli, Luis G.
core +2 more sources
Interaction of antithrombin III with surface-immobilized albumin-heparin conjugates [PDF]
, 1995 The interaction between antithrombin III (ATIII) and albumin-heparin conjugates covalently coupled onto carboxylated polystyrene beads either in buffer containing albumin or in plasma was studied using 14C-labeled ATIII.
Delden, C.J. van +2 more
core +2 more sources
PocketMatch: A new algorithm to compare binding sites in protein structures [PDF]
, 2008 Background: Recognizing similarities and deriving relationships among protein molecules is a fundamental requirement in present-day biology.
A Argyrou +25 more
core +6 more sources
Local sequence features that influence AP-1 cis-regulatory activity [PDF]
, 2018 In the genome, most occurrences of transcription factor binding sites (TFBS) have no cis-regulatory activity, which suggests that flanking sequences contain information that distinguishes functional from nonfunctional TFBS.
Chaudhari, Hemangi G, Cohen, Barak A
core +2 more sources