Results 11 to 20 of about 1,627,769 (335)
Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]
, 2012 Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias +5 more
core +7 more sources
Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. [PDF]
PLoS Pathogens, 2013 Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein.
Sowmya Sampath +9 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Extensive studies of the structure–function relationship of antibodies have established that conventional immunoglobulins contain two copies of the antigen-binding fragment (Fab), each of which serves as an autonomous and complete unit for ...
T. Hattori +14 more
semanticscholar +1 more source
Binding site of toxic protein from Arthrinium phaeospermum on plasmalemma of hybrid bamboo
浙江大学学报. 农业与生命科学版, 2012 To explore the binding site of toxic protein from Arthrinium phaeospermum on plasmalemma of hybrid bamboo and the binding activities of different hybrid bamboo varieties, based on the separation and purification of toxic protein by a low-pressure ...
LI Shu-jiang, ZHU Tian-hui
doaj +1 more source
Advanced Science, 2023 Antibody‐based therapies could be led astray when target receptors are expressed on nontarget sites, and the on‐target toxicity poses critical challenges to clinical applications. Here, a biomimetic indirect active targeting (INTACT) strategy is proposed
Zhongjie Tang +9 more
doaj +1 more source
Modelling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion [PDF]
, 2016 We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface.
Argungu, Maryam +8 more
core +1 more source
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites
bioRxiv, 2016 We describe Cleavage Under Targets and Release Using Nuclease (CUT&RUN), a chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the supernatant for paired-end DNA
P. Skene, S. Henikoff
semanticscholar +1 more source
Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]
, 2010 No ...
Bjorkman, Pamela J., Klein, Joshua S.
core +7 more sources
Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.
PLoS ONE, 2016 We describe three recombinant engineered antibodies against three recombinant epitope tags, constructed with divalent binding arms to recognize divalent epitopes and so achieve high affinity and specificity.
Hongyu Zhao +3 more
doaj +1 more source
Scientific Reports, 2022 The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strategy for transporting protein-based drugs into
Andrés de la Rosa +8 more
doaj +1 more source