Results 21 to 30 of about 1,627,769 (335)

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

PLoS ONE, 2011
BackgroundCockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited.
Jill Glesner, Sabina Wünschmann, Mi Li, Alla Gustchina, Alexander Wlodawer, Martin Himly, Martin D Chapman, Anna Pomés   +7 more
doaj   +1 more source

Identifying vaccine escape sites via statistical comparisons of short-term molecular dynamics

Biophysical Reports, 2022
The identification of viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution.
Madhusudan Rajendran, Maureen C. Ferran, Gregory A. Babbitt   +2 more
doaj   +1 more source

Viral Receptor-Binding Site Antibodies with Diverse Germline Origins [PDF]

Cell, 2015
Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site (RBS). From characteristics of an influenza-virus RBS-directed antibody, we devised a signature motif to search for similar antibodies.
Schmidt, Aaron G., Therkelsen, Matthew D., Stewart, Shaun, Kepler, Thomas B., Liao, Hua-Xin, Moody, M. Anthony, Haynes, Barton F., Harrison, Stephen C.   +7 more
openaire   +2 more sources

Hsp-90 and the biology of nematodes [PDF]

, 2009
BACKGROUND: Hsp-90 from the free-living nematode Caenorhabditis elegans is unique in that it fails to bind to the specific Hsp-90 inhibitor, geldanamycin (GA).
Devaney, E., Emes, R.D., Gillan, V., Him, N.A.I.I.N., Maitland, K.   +4 more
core   +3 more sources

Possible molecular basis for macromolecular antigen attachment to host cells: their immune complex with plasma antibodies have unoccupied binding sites enabling binding to smaller ligands

AIMS Molecular Science, 2017
Macromolecules such as lipoprotein(a) and antigens of Streptococcus mutans that cause dental infections accumulate in perivascular cells in inflammatory vascular disorders though they do not bind host cells directly.
Genu George, Sumita K. Chellappan, Mandagini Geetha, Padinjaradath S. Appukuttan   +3 more
doaj   +1 more source

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

Modern Pathology, 2019
Programmed cell death ligand-1 (PD-L1) expression levels in patient tumor samples have proven clinical utility across various cancer types. Several independently developed PD-L1 immunohistochemical (IHC) predictive assays are commercially available ...
Nicola L. Lawson, Carly I Dix, P. Scorer, C. Stubbs, Edmond Wong, L. Hutchinson, E. McCall, M. Schimpl, Emma DeVries, Jill Walker, G. Williams, J. Hunt, C. Barker   +12 more
semanticscholar   +1 more source

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]

, 2017
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa, Benner, Christopher, Hargreaves, Diana C, Kelso, Timothy WR, Porter, Devin K, Shokhirev, Maxim N   +5 more
core   +1 more source

The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Scientific Reports, 2022
SARS-CoV-2 is the pathogen responsible for COVID-19 that has claimed over six million lives as of July 2022. The severity of COVID-19 motivates a need to understand how it could evolve to escape potential treatments and to find ways to strengthen ...
Jonathan E. Barnes, Peik K. Lund-Andersen, Jagdish Suresh Patel, F. Marty Ytreberg   +3 more
doaj   +1 more source

Peptide Linked Diacetylene Amphiphiles for Detection of Epitope Specific Antibodies

Chemosensors, 2022
Antibodies produced in response to adaptive immunity provide a receptor with multiple sites for binding to a distinct epitope of an antigen. Determining antibody levels to specific antigens has important clinical applications in assessing immune status ...
Natalie Tran, Priyanka Shiveshwarkar, Justyn Jaworski   +2 more
doaj   +1 more source

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. [PDF]

, 2011
BackgroundCell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Liao, Kan, Liu, Yang, Wang, Wenqi
core   +2 more sources