Results 181 to 190 of about 1,488,373 (296)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface. [PDF]

Nat Commun
Burendei B, Kaplan JP, Orellana GM, Liman ER, Forli S, Ward AB.   +5 more
europepmc   +1 more source

Dynamic aspects of the heme-binding site in phylogenetically distant myoglobins

, 1987
Ettore Bismuto, Gaetano Irace, Giovanni Colonna, David M. Jameson, Enrico Gratton   +4 more
openalex   +2 more sources

Computational prediction of miRNA binding sites in mRNA of colorectal cancer candidate genes

, 2020

openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Quantifying transcription factor specificity with advanced DNA universal microarrays featuring long and modified binding sites. [PDF]

Nucleic Acids Res
Bayer Y, O'Hagan MP, Miodownik I, Afek A.   +3 more
europepmc   +1 more source

Identification of a Lysine Residue in the NADH-Binding Site of Salicylate Hydroxylase from Pseudomonas putida S-1

, 1995
Kenzi Suzuki, Mitsuo Mizuguchi, Tomoharu Gomi, Eiji Itagaki   +3 more
openalex   +2 more sources

Antibody Binding Site [PDF]

, 2020
openaire   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

CFTR_TL: Transfer Learning-Enhanced Prediction of CFTR ATP Binding Sites with Multi-Window Convolutional Neural Networks. [PDF]

ACS Omega
Lee YC, Chang YY, Jhang WE, Le VT, Wei SS, Ou YY.   +5 more
europepmc   +1 more source