Results 181 to 190 of about 8,324,980 (383)

Disease variants alter transcription factor levels and methylation of their binding sites

Nature Genetics, 2016
M. Bonder, R. Luijk, D. Zhernakova, M. Moed, Patrick Deelen, M. Vermaat, M. van Iterson, F. van Dijk, M. van Galen, J. Bot, R. Slieker, P. M. Jhamai, M. Verbiest, H. Suchiman, M. Verkerk, R. van der Breggen, J. V. van Rooij, N. Lakenberg, W. Arindrarto, S. Kiełbasa, I. Jonkers, Peter van ’t Hof, I. Nooren, M. Beekman, J. Deelen, D. van Heemst, A. Zhernakova, E. Tigchelaar, M. Swertz, A. Hofman, A. Uitterlinden, R. Pool, J. van Dongen, J. Hottenga, C. Stehouwer, C. V. D. van der Kallen, C. Schalkwijk, L. H. van den Berg, E. V. van Zwet, H. Mei, Yang Li, M. Lemire, T. Hudson, P. Slagboom, C. Wijmenga, J. Veldink, M. V. van Greevenbroek, C. V. van Duijn, D. Boomsma, A. Isaacs, R. Jansen, J. V. van Meurs, P. ’. ’t Hoen, L. Franke, B. Heijmans   +54 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes

Cell, 2006
K. Miranda, T. Huynh, Yvonne Tay, Yen-Sin Ang, W. Tam, A. Thomson, B. Lim, I. Rigoutsos   +7 more
semanticscholar   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Aminoacyl-tRNA binding at the recognition site is the first step of the elongation cycle of protein synthesis.

, 1977
James A. Lake
openalex   +1 more source

Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers

Proceedings of the National Academy of Sciences of the United States of America, 2016
B. Miotto, Zhe Ji, K. Struhl
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers

Proceedings of the National Academy of Sciences of the United States of America, 2016
E. Farley, K. M. Olson, Wei Zhang, D. Rokhsar, M. Levine   +4 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Bovine serum albumin. Study of the fatty acid and steroid binding sites using spin-labeled lipids.

, 1975
Joel D. Morrisett, Henry J. Pownall, AM Gotto   +2 more
openalex   +1 more source