Results 211 to 220 of about 1,488,373 (296)

Systematic structural and functional analysis of metal-binding sites in native proteomes

Quast J, Pagotto A, Separovich R, Dünnebacke M, Gillet L, Luo X, Züger E, Magnusson G, Correia M, Ciofalo C, Andreini C, Rosato A, Beltrao P, Zamboni N, de Souza N, Picotti P.   +15 more
europepmc   +1 more source

RNA language model and graph attention network for RNA and small molecule binding sites prediction. [PDF]

Bioinformatics
Sun S, Yang J, Gao L, Li P, Liu Y.
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Identifying 14-3-3 interactome binding sites with deep learning.

Digit Discov
van Weesep L, Özçelik R, Pennings M, Criscuolo E, Ottmann C, Brunsveld L, Grisoni F.   +6 more
europepmc   +1 more source

Identification of druggable binding sites and small molecules as modulators of TMC1. [PDF]

Commun Biol
De-la-Torre P, Martínez-García C, Gratias P, Mun M, Santana P, Akyuz N, González W, Indzhykulian AA, Ramírez D.   +8 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

InDeepNet: a web platform for predicting functional binding sites in proteins using InDeep. [PDF]

Nucleic Acids Res
Mareuil F, Torchet R, Ruano LC, Mallet V, Nilges M, Bouvier G, Sperandio O.   +6 more
europepmc   +1 more source

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

Kushani Shah, Eleni Anastasakou, Leinal Sejour, Yufei Wang, León Wert-Lamas, Christopher Rauchet, Sabine Studer, Simon Goller, R Distel, Wayne A. Marasco, L. Perera, Ioannis S. Vlachos, Carl D. Novina   +12 more
openalex   +1 more source

Metal Binding Site [PDF]

, 2020
openaire   +1 more source