Results 211 to 220 of about 8,324,980 (383)

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus. [PDF]

J Virol
Busuttil K, Pittman N, Zachary J, Halder S, Geilen L, Singh A, Misseldine A, Kaplonek P, Chipman P, Heimburg-Molinaro J, Seeberger PH, Mietzsch M, Bennett AD, McKenna R.   +13 more
europepmc   +1 more source

Evidence That Tetrodotoxin and Saxitoxin Act at a Metal Cation Binding Site in the Sodium Channels of Nerve Membrane [PDF]

, 1974
Richard A. Henderson, J. M. Ritchie, Gary R. Strichartz   +2 more
openalex   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

CH-π interactions confer orientational flexibility in protein-carbohydrate binding sites. [PDF]

J Biol Chem
Keys AM, Kastner DW, Kiessling LL, Kulik HJ.   +3 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Development and Application of Radioactive Ligands Targeting Fibroblasts with Albumin-Binding Sites. [PDF]

Mol Cancer Ther
Wu T, Yang Z, Tang S, Yuan H, Liu Y, Li H, Liu N, Huang Z, Chen Y, Zhou Z.   +9 more
europepmc   +1 more source

Assessing computational tools for the discovery of transcription factor binding sites

Nature Biotechnology, 2005
M. Tompa, Nan Li, T. Bailey, G. Church, B. Moor, E. Eskin, A. Favorov, M. Frith, Yutao Fu, W. Kent, V. Makeev, A. Mironov, William Stafford Noble, G. Pavesi, G. Pesole, M. Régnier, Nicolas Simonis, S. Sinha, G. Thijs, J. Helden, Mathias Vandenbogaert, Z. Weng, C. Workman, Chun Jimmie Ye, Zhou Zhu   +24 more
semanticscholar   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

RNA language model and graph attention network for RNA and small molecule binding sites prediction. [PDF]

Bioinformatics
Sun S, Yang J, Gao L, Li P, Liu Y.
europepmc   +1 more source

The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.

, 1975
MR Schlabach, GW Bates
openalex   +1 more source