Results 221 to 230 of about 1,507,897 (295)

Quantifying transcription factor specificity with advanced DNA universal microarrays featuring long and modified binding sites. [PDF]

Nucleic Acids Res
Bayer Y, O'Hagan MP, Miodownik I, Afek A.   +3 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

CH-π interactions confer orientational flexibility in protein-carbohydrate binding sites. [PDF]

J Biol Chem
Keys AM, Kastner DW, Kiessling LL, Kulik HJ.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus. [PDF]

J Virol
Busuttil K, Pittman N, Zachary J, Halder S, Geilen L, Singh A, Misseldine A, Kaplonek P, Chipman P, Heimburg-Molinaro J, Seeberger PH, Mietzsch M, Bennett AD, McKenna R.   +13 more
europepmc   +1 more source

MOESM9 of DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis

, 2018
Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pinduyrin, Laura Breimann, Helmut Blum, Bas van Steensel, Anne-Kathrin Classen   +7 more
openalex   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

CFTR_TL: Transfer Learning-Enhanced Prediction of CFTR ATP Binding Sites with Multi-Window Convolutional Neural Networks. [PDF]

ACS Omega
Lee YC, Chang YY, Jhang WE, Le VT, Wei SS, Ou YY.   +5 more
europepmc   +1 more source

Additional file 1: Table S1. of Polymorphism in microRNA-binding site in HNF1B influences the susceptibility of type 2 diabetes mellitus: a population based caseâ control study

, 2015
Naoki Goda, Haruna Murase, Nobuhiko Kasezawa, Toshinao Goda, Kimiko Yamakawa‐Kobayashi   +4 more
openalex   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source