Results 221 to 230 of about 1,488,373 (296)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize. [PDF]

Nat Genet
Engelhorn J, Snodgrass SJ, Kok A, Seetharam AS, Schneider M, Kiwit T, Singh A, Banf M, Doan DTH, Khaipho-Burch M, Runcie DE, Sánchez-Camargo VA, Bader R, Vladimir Torres-Rodriguez J, Sun G, Stam M, Fiorani F, Beier S, Schnable JC, Bass HW, Hufford MB, Stich B, Frommer WB, Ross-Ibarra J, Hartwig T.   +24 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Fine tuning wheat heading time through genome editing of transcription factor binding sites in Ppd-1 gene promoter. [PDF]

Sci Rep
Kiseleva AA, Timonova EM, Berezhnaya AA, Kolozhvari AE, Kochetov AV, Salina EA.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy. [PDF]

Nucleic Acids Res
Sweetapple L, Kosek DM, Banijamali E, Becker W, Müller J, Karadiakos C, Baronti L, Guzzetti I, Schritt D, Chen A, Andersson ER, Petzold K.   +11 more
europepmc   +1 more source

Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function

, 2000
MinKyung Yi, Derk E. Schultz, Stanley M. Lemon   +2 more
openalex   +2 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

In silico identification of substrate-binding sites in type-1A α-synuclein amyloids. [PDF]

Biophys J
Parate S, Buratti F, Eriksson LA, Wittung-Stafshede P.   +3 more
europepmc   +1 more source

Crystal Structures of the Mnk2 Kinase Domain Reveal an Inhibitory Conformation and a Zinc Binding Site

, 2005
Ralf Jauch, Stefan Jäkel, Catharina Netter, Kay Schreiter, Babette Aicher, Herbert Jäckle, M.C. Wahl   +6 more
openalex   +2 more sources