Highly conserved ion binding sites are not all functionally relevant in mouse KCC4. [PDF]
Front Mol BiosciBecker L +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger +2 more
wiley +1 more source
CryptoBench: cryptic protein-ligand binding sites dataset and benchmark. [PDF]
BioinformaticsŠkrhák V +4 more
europepmc +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Comparative evaluation of methods for the prediction of protein-ligand binding sites. [PDF]
J CheminformUtgés JS, Barton GJ.
europepmc +1 more source
The distribution of α‐bungarotoxin binding sites on mammalian skeletal muscle developing in vivo
, 1977 Stuart Bevan, Joe Henry Steinbach
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
PinMyMetal: a hybrid learning system to accurately model transition metal binding sites in macromolecules. [PDF]
Nat CommunZhang H +9 more
europepmc +1 more source
Studies of the oxygen binding site of cytochrome P-450. Nitric oxide as a spin-label probe.
, 1978 David H. O’Keeffe +2 more
openalex +1 more source
Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. [PDF]
, 1977 J H Oppenheimer +3 more
openalex +1 more source