Results 241 to 250 of about 2,663,361 (333)

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

Kushani Shah, Eleni Anastasakou, Leinal Sejour, Yufei Wang, León Wert-Lamas, Christopher Rauchet, Sabine Studer, Simon Goller, R Distel, Wayne A. Marasco, L. Perera, Ioannis S. Vlachos, Carl D. Novina   +12 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize. [PDF]

Nat Genet
Engelhorn J, Snodgrass SJ, Kok A, Seetharam AS, Schneider M, Kiwit T, Singh A, Banf M, Doan DTH, Khaipho-Burch M, Runcie DE, Sánchez-Camargo VA, Bader R, Vladimir Torres-Rodriguez J, Sun G, Stam M, Fiorani F, Beier S, Schnable JC, Bass HW, Hufford MB, Stich B, Frommer WB, Ross-Ibarra J, Hartwig T.   +24 more
europepmc   +1 more source

SpatConv Enables the Accurate Prediction of Protein Binding Sites by a Pretrained Protein Language Model and an Interpretable Bio-spatial Convolution

Mingming Guan, Jiyun Han, Shizhuo Zhang, Hongyu Zheng, Juntao Liu   +4 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Systematic structural and functional analysis of metal-binding sites in native proteomes

Quast J, Pagotto A, Separovich R, Dünnebacke M, Gillet L, Luo X, Züger E, Magnusson G, Correia M, Ciofalo C, Andreini C, Rosato A, Beltrao P, Zamboni N, de Souza N, Picotti P.   +15 more
europepmc   +1 more source

Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy. [PDF]

Nucleic Acids Res
Sweetapple L, Kosek DM, Banijamali E, Becker W, Müller J, Karadiakos C, Baronti L, Guzzetti I, Schritt D, Chen A, Andersson ER, Petzold K.   +11 more
europepmc   +1 more source

Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors^,

, 2007
L.L. Lovelace, Lydia M. Gibson, Lebioda
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Exploring the binding sites of VRT534 at Cx26 as a putative chemical chaperone for targeted treatment of hereditary hearing disorders. [PDF]

Front Med (Lausanne)
Harre J, Wang D, Warnecke A, Zeilinger C.   +3 more
europepmc   +1 more source