Results 31 to 40 of about 8,224,245 (384)

The Functional Consequences of Variation in Transcription Factor Binding [PDF]

, 2013
One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in ...
Cusanovich, Darren A., Gilad, Yoav, Pavlovic, Bryan, Pritchard, Jonathan K.   +3 more
core   +8 more sources

The adaptors Grb10 and Grb14 are calmodulin-binding proteins [PDF]

, 2017
We identified the Grb7 family members, Grb10 and Grb14, as Ca2+-dependent CaM-binding proteins using Ca2+-dependent CaM-affinity chromatography as we previously did with Grb7.
Angrist, Audran, Bai, Benaim, Berchtold, Blagitko, Chin, Chu, Cooney, Dagher, Daly, Daly, Depetris, Depetris, Dey, Dong, Duval, Frantz, García-Palmero, García-Palmero, García-Palmero, Giorgetti-Peraldi, Han, Han, Hansen, He, Hoeflich, Jurado, Kairouz, Kasus-Jacobi, Laemmli, Laviola, Li, Li, Liu, Lucas-Fernández, Mano, Manser, Manser, Maqani, Margolis, Margolis, Martin-Nieto, Morrione, Morrione, Nantel, O'Neil, O'Neill, Ooi, Ramos, Reilly, San José, Shen, Shen, Stein, Tanaka, Tanaka, Tanaka, Vecchione, Vetter, Villalobo, Villarroel   +61 more
core   +1 more source

Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins [PDF]

, 2003
A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting ...
Berman, Helen M, Jones, Susan, Shanahan, Hugh P, Thornton, Janet M   +3 more
core   +4 more sources

Predicting effective microRNA target sites in mammalian mRNAs

eLife, 2015
MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches ...
Vikram Agarwal, G. Bell, Jin-Wu Nam, D. Bartel   +3 more
semanticscholar   +1 more source

Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screening

Virus Research, 2022
The key structure of the interface between the spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human angiotensin-converting enzyme 2 (hACE2) acts as an essential switch for cell entry by the virus and drugs targets ...
Xiaopeng Hu, Jiahua Cui, Jun Chen, Shujuan Du, Xinyu Wang, Yabin Zhang, Jiajun Qian, Haifeng Chen, Fang Wei, Qiliang Cai, Jinping Jia, Ji Wu   +11 more
doaj   +1 more source

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

The metal binding site of zoocin A [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2008
Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Gary L. Sloan, Robin S. Simmonds, Russell Timkovich, Yinghua Chen   +3 more
openaire   +3 more sources

Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry

Molecules, 2019
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng, Yanyan Zhang, Wei Zheng, Qun Luo, Juanjuan Han, Jian’an Liu, Yao Zhao, Feifei Jia, Kui Wu, Fuyi Wang   +9 more
doaj   +1 more source

Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model [PDF]

Genomics & Informatics, 2017
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.
Suresh Kumar
doaj   +1 more source

Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

Molecules, 2018
Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates.
Simone Queiroz Pantaleão, Eric Allison Philot, Pedro Túlio de Resende-Lara, Angélica Nakagawa Lima, David Perahia, Maria Atanassova Miteva, Ana Ligia Scott, Kathia Maria Honorio   +7 more
doaj   +1 more source