Results 31 to 40 of about 1,113,152 (202)
Frontiers in Endocrinology, 2017 Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen +2 more
doaj +1 more source
The adaptors Grb10 and Grb14 are calmodulin-binding proteins [PDF]
, 2017 We identified the Grb7 family members, Grb10 and Grb14, as Ca2+-dependent CaM-binding proteins using Ca2+-dependent CaM-affinity chromatography as we previously did with Grb7.
Angrist +61 more
core +1 more source
Molecules, 2019 The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng +9 more
doaj +1 more source
Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins [PDF]
, 2003 A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting ...
Berman, Helen M +3 more
core +4 more sources
Ethanol binding sites on proteins
Journal of Molecular Graphics and Modelling, 2017 This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V. +2 more
openaire +4 more sources
The iron binding-sites of chicken ovotransferrin [PDF]
, 1986 We have shown previously that the EXAFS spectrum of diferric chicken ovotransferrin (Fe2COT) can only be adequately simulated assuming a split first shell co-ordination [1].
Evans, RW +3 more
core +2 more sources
A client‐binding site of Cdc37 [PDF]
The FEBS Journal, 2005 The molecular chaperone Hsp90 is distinct from Hsp70 and chaperonin in that client proteins are apparently restricted to a subset of proteins categorized as cellular signaling molecules. Among these, many specific protein kinases require the assistance of Hsp90 and its co‐chaperone Cdc37/p50 for their biogenesis.
Kazuya Terasawa, Yasufumi Minami
openaire +3 more sources
Return of the Electric Binding Site [PDF]
The Journal of General Physiology, 2008 The BK-type Ca2+-activated K+ channel has been the subject of increasingly detailed mechanistic study since the first recordings of this channel were obtained more than 25 years ago (Pallotta et al., 1981; Latorre et al., 1982; Magleby, 2003; and references therein).
openaire +2 more sources
The evolution of complex gene regulation by low specificity binding sites
, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B. +1 more
core +1 more source
The Na+ Binding Site of Thrombin [PDF]
Journal of Biological Chemistry, 1995 Thrombin is an allosteric serine protease existing in two forms, slow and fast, targeted toward anticoagulant and procoagulant activities. The slow --> fast transition is induced by Na+ binding to a site contained within a cylindrical cavity formed by three antiparallel beta-strands of the B-chain (Met180-Tyr184a, Lys224-Tyr228, and Val213-Gly219 ...
Enrico Di Cera +6 more
openaire +3 more sources