Results 71 to 80 of about 72,929 (276)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Design of bio-nanosystems for oral delivery of functional compounds [PDF]

, 2014
Nanotechnology has been referred to as one of the most interesting topics in food technology due to the potentialities of its use by food industry. This calls for studying the behavior of nanosystems as carriers of biological and functional compounds ...
A Johnston, A Maltais, A Noack, A Totosaus, A-J Choi, AC Pinheiro, AC Pinheiro, AC Pinheiro, AH Sneharani, Ana C. Pinheiro, Ana I. Bourbon, António A. Vicente, AR Madureira, AS Angelatos, AS Hoffman, B Gyarmati, B Hu, B Sarmento, BGS Medeiros, C Bengoechea, C Jo, C Qian, C Schmitt, C Zhao, CC Berton-Carabin, CC Lin, CE Mora-Huertas, CJ Ochs, CM Bryant, CP Reis, CS Chern, D Guzey, D Quintanar-Guerrero, DJ McClements, DJ McClements, DJ McClements, DJ McClements, DJ McClements, DM Mulvihill, E Acosta, F Liu, F Shakeel, F-A Zhang, FM Goycoolea, G Filipcsei, G Spigno, GR Ziegler, H Moskowitz, HD Silva, HD Silva, HL Wong, HM Said, Hélder D. Silva, I Tokarev, J Hu, J Kopecek, J Ubbink, J Weiss, JC Wang, JK Oh, JM Barichello, JP Rao, JS Negi, JS Patil, K Ahmed, KN Otto, KS Soppimath, L Chen, L Loretta, L Salvia-Trujillo, L Yuxi, M Cushen, M Rubinstein, M Sessa, M Siegrist, Maria A. Azevedo, María L. Flores-López, Melissa C. Rivera, Miguel A. Cerqueira, MM Villiers de, N Mantilla, N Öztürk, NA Peppas, OL Ramos, P Bertrand, P Calvo, P Lertsutthiwong, P Sanguansri, P Zimet, Philippe E. Ramos, PN Ezhilarasi, Q Huang, Q Li, R Arunkumar, RK Das, S Beyer, S Cai, S Chakraborty, S Das, S Kawaguchi, S Neethirajan, S Shrivastava, S Shu, S Ye, S Yu, SK Shukla, SKH Gulrez, SL Pal, T Aoki, T Helgason, T Shiga, T Tokle, T Vermonden, TR Hoare, U Bazylińska, VJ Mohanraj, W Mehnert, W Somchue, WE Hennink, Y Li, Y Luo, Y Wang, Y Wang, YB Schuetz, YS Gu, Z Fang, Z Hou, Óscar L. Ramos   +127 more
core   +1 more source

Iron Bio-accessibility and Nutritional Attributes of Selected Disease Specific Commercial Formulations

Defence Life Science Journal, 2017
<p>Iron deficiency is the most common form of malnutrition in the world, affecting more than 2 billion people globally. Food labeling is an important tool that provides information on the nutritional composition data to consumers. However, the information on bio accessibility values is limited; therefore, the aim of the present study is to ...
Asna Urooj, Seema Siddiqi, Lakshmi, S.
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A Comparative In Vitro Digestion Study of Three Lipid Delivery Systems for Arachidonic and Docosahexaenoic Acids Intended to Be Used for Preterm Infants

Molecules
It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible.
Blanca Pardo de Donlebún, Assamae Chabni, Celia Bañares, Carlos F. Torres   +3 more
doaj   +1 more source

Effect of Steaming Processing on Phenolic Profiles and Cellular Antioxidant Activities of Castanea mollissima

Molecules, 2019
The intention of this study was to investigate the effect of steaming processing on phenolic profiles and antioxidant activities in chestnuts. Steaming processing at different times and temperatures depicted diverse impacts on free and bound fractions ...
Fangyuan Zhang, Fengyuan Liu, Arshad Mehmood Abbasi, Xiaoxiao Chang, Xinbo Guo   +4 more
doaj   +1 more source

Tritordeum as an Innovative Alternative to Wheat: A Comparative Digestion Study on Bread

Molecules, 2022
Tritordeum results from the crossbreeding of a wild barley (Hordeum chilense) species with durum wheat (Triticum turgidum spp. turgidum). This hexaploid crop exhibits agronomic and rheological characteristics like soft wheat, resulting in an innovative ...
Chiara Nitride, Giovanni D’Auria, Andrea Dente, Viola Landolfi, Gianluca Picariello, Gianfranco Mamone, Massimo Blandino, Raffaele Romano, Pasquale Ferranti   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A novel two-step sequential bioaccessibility test for potentially toxic elements in inhaled particulate matter transported into the gastrointestinal tract by mucociliary clearance [PDF]

, 2017
A novel two-step sequential extraction has been developed to assess the bioaccessibility of As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn in airborne particulate matter following inhalation and transport into the human gastrointestinal tract by mucociliary ...
Alpofead, Jawad Ali Hussein, Davidson, Christine M., Littlejohn, David   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source