Results 41 to 50 of about 534,947 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An acidic morpholine derivative containing glyceride from thraustochytrid, Aurantiochytrium

Scientific Reports, 2021
A novel acidic morpholine-derivative containing glyceride (M-glyceride) was isolated from the cells of two strains of the thraustochytrid, Aurantiochytrium. The glyceride accounted for approximately 0.1 -0.4% of the lyophilized cells.
Kunimitsu Kaya, Fujio Shiraishi, Tetsuo Iida, Masaki Yamada, Tomoharu Sano   +4 more
doaj   +1 more source

In Vitro and In Silico Investigations of Natural Compounds with Predicted Activity against Neuroblastomas

Chemistry Proceedings, 2022
In the present study, the ability of an ethanolic extract from Stokesia laevis to inhibit the development of human glioblastoma cell line U87 has been investigated. Cytotoxic activity has been estimated at 78% in comparison to normal human astrocyte cell
Lucia Camelia Pirvu, Georgeta Neagu, Özge Çığ, Adrian Albulescu, Lucia Pintilie, Amalia Stefaniu   +5 more
doaj   +1 more source

3D printing of PEEK-based medical devices [PDF]

, 2019
open access articlePolyether-ether-ketone (PEEK) is an excellent thermoplastic alternative to metallic biomaterials which is used for loadbearing applications due to its high strength and stiffness, and biocompatibility with no cytotoxic effects ...
Seitz, Herman, Shakeri, Mohsen, Tafaoli-Masoule, Mojtaba, Vaezi, Mohammad, Zahedi, S. A.   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

OrgTrace – No Difference in Levels of Bioactive Compounds found in Crops from Selected Organic and Conventional Cultivation Systems [PDF]

, 2011
The objective of the present study was to compare the content of selected bioactive compounds in organically and conventionally grown crops, and to evaluate if the ability of the crops to synthesize selected secondary metabolites was systematically ...
Bysted, Anette, Halekoh, Ulrich, Husted, Søren, Knuthsen, Pia, Laursen, Kristian Holst, Madsen, Katja H, Nielsen , John, Soeltoft, Malene   +7 more
core  

Bioactive compounds from marine actinomycetes [PDF]

Indian Journal of Microbiology, 2008
Actinomycetes are one of the most efficient groups of secondary metabolite producers and are very important from an industrial point of view. Among its various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules.
Renu, Solanki, Monisha, Khanna, Rup, Lal
openaire   +2 more sources

Polyphenols as promising bioactive compounds

Problems of Nutrition, 2023
Polyphenols are diverse and widespread bioactive plant-based compounds. These compounds are found in various foods such as berries, fruits, vegetables, cereals, nuts, coffee, cacao, spices, seeds. They are divided into phenolic acids, stilbenes, flavonoids, lignans depending on their molecular structure. They attract the attention of researchers due to
T.N. Bobrysheva, G.S. Anisimov, M.S. Zolotoreva, D.V. Bobryshev, R.O. Budkevich, A.A. Moskalev   +5 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Opioids in COVID-19: Two Sides of a Coin

Frontiers in Pharmacology, 2022
Introduction: The treatment of most severe COVID-19 patients included the large-scale use of sedatives and analgesics–possibly in higher doses than usual–which was reported in the literature.
Camila Vantini Capasso Palamim, Camila Vantini Capasso Palamim, Matheus Negri Boschiero, Matheus Negri Boschiero, Aléthea Guimarães Faria, Aléthea Guimarães Faria, Felipe Eduardo Valencise, Felipe Eduardo Valencise, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson   +9 more
doaj   +1 more source