Results 41 to 50 of about 268,312 (268)

Opioids in COVID-19: Two Sides of a Coin

Frontiers in Pharmacology, 2022
Introduction: The treatment of most severe COVID-19 patients included the large-scale use of sedatives and analgesics–possibly in higher doses than usual–which was reported in the literature.
Camila Vantini Capasso Palamim, Camila Vantini Capasso Palamim, Matheus Negri Boschiero, Matheus Negri Boschiero, Aléthea Guimarães Faria, Aléthea Guimarães Faria, Felipe Eduardo Valencise, Felipe Eduardo Valencise, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson   +9 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Improvement of the Oxidative Stability of Rosehip, Hemp, and Passion Fruit Oils by the Addition of Monocyclic Phenols as Antioxidants

Antioxidants
Caffeic, syringic, and protocatechuic acids are phenolic acids with important antioxidant activity. In this work we studied how the oxidative stability of rosehip, hemp, and passion fruit oils improves with the addition of these antioxidant acids.
Gloria Castellano, Irene Sarrión, Carmen Fagoaga, Ricardo M. Giménez-Núñez, Enrique Gómez-Gómez, Francisco Torrens   +5 more
doaj   +1 more source

Isolation and Genetic Identification of Endophytic Lactic Acid Bacteria From the Amazonian Açai Fruits: Probiotics Features of Selected Strains and Their Potential to Inhibit Pathogens

Frontiers in Microbiology, 2021
The açai palm (Euterpe oleracea) is native to the Amazon basin, a humid tropical forest. High levels of total mesophilic bacteria with high diversity have been consistently reported in açai fruits.
Suenne Taynah Abe Sato, Joana Montezano Marques, Joana Montezano Marques, André da Luz de Freitas, Raphaela Cristina Sanches Progênio, Márcio Roberto Teixeira Nunes, Janaína Mota de Vasconcelos Massafra, Fábio Gomes Moura, Hervé Rogez   +8 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Euterpe oleracea Mart.) stone in rats

Toxicology Reports, 2021
The biological and pharmacological properties of natural polyphenols of the extract of Euterpe oleracea stone (EEOS) are associated with the central nervous system (CNS).
Nilton Akio Muto, Moisés Hamoy, David Cristian Rodrigues Lucas, Bruno Brito Teixeira, Adrielle Felicia Santos Almeida, Thamires de Castro Navegantes, Vaniza Sheila de Sousa Ferreira de Sá, Brenda Pinto de Moraes, João Paulo do Vale Medeiros, Yasmin Amorim dos Santos, Claúdia Quintino da Rocha, Vanessa Joia de Mello, Hervé Rogez   +12 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Physicochemical Characterization of Bioactive Compounds in Nanocarriers

Current Pharmaceutical Design, 2020
The encapsulation of bioactive compounds is an emerging technique for finding new medicines since it provides protection against ambient degradation factors before reaching the target site. Nanotechnology provides new methods for encapsulating bioactive compounds and for drug carrier development.
Rafaella M. Barros, Maísa S. de Oliveira, Kammila M. N. Costa, Mariana R. Sato, Karen L. M. Santos, Bolívar P. G. de L. Damasceno, Teresa Cuberes, Joáo A. Oshiro-Junior   +7 more
openaire   +3 more sources

Bioactive Compounds in Functional Meat Products [PDF]

Molecules, 2018
Meat and meat products are a good source of bioactive compounds with positive effect on human health such as vitamins, minerals, peptides or fatty acids. Growing food consumer awareness and intensified global meat producers competition puts pressure on creating new healthier meat products.
Ewelina Pogorzelska-Nowicka, Atanas Atanasov, Jarosław Horbańczuk, Agnieszka Wierzbicka   +3 more
openaire   +5 more sources