Results 41 to 50 of about 346,763 (316)

Bioactive peptides with antioxidant and antihypertensive properties, obtained from chachafruto seed flour (Erythrina edulis)

, 2022
: INTRODUCTION Hypertension is an important risk factor for atherosclerosis and therefore predisposes to coronary, cerebrovascular and renal diseases, (Mejías C et al., 2004; Torruco-Uco et al., 2009).
Acevedo Fernández, Juan José, Zapata Montoya, José Edgar, Guerra Almonacid, Carlos Martín   +2 more
core  

Antibacterial potential of indigenous red mangrove (Rhizophora racemosa) fungal endophytes and bioactive compounds identification [PDF]

, 2016
The antibacterial activity of indigenous red mangrove leaves- endophytic fungi against marine pathogenic bacteria and bioactive compounds identification and quantification were carried out.
C. N. Ariole, A. E. Akinduyite
core   +1 more source

In Vitro and In Silico Investigations of Natural Compounds with Predicted Activity against Neuroblastomas

Chemistry Proceedings, 2022
In the present study, the ability of an ethanolic extract from Stokesia laevis to inhibit the development of human glioblastoma cell line U87 has been investigated. Cytotoxic activity has been estimated at 78% in comparison to normal human astrocyte cell
Lucia Camelia Pirvu, Georgeta Neagu, Özge Çığ, Adrian Albulescu, Lucia Pintilie, Amalia Stefaniu   +5 more
doaj   +1 more source

Physicochemical Characterization of Bioactive Compounds in Nanocarriers

Current Pharmaceutical Design, 2020
The encapsulation of bioactive compounds is an emerging technique for finding new medicines since it provides protection against ambient degradation factors before reaching the target site. Nanotechnology provides new methods for encapsulating bioactive compounds and for drug carrier development.
Rafaella M. Barros, Maísa S. de Oliveira, Kammila M. N. Costa, Mariana R. Sato, Karen L. M. Santos, Bolívar P. G. de L. Damasceno, Teresa Cuberes, Joáo A. Oshiro-Junior   +7 more
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Natural Occurring β-Peptides: A Fascinating World of Bioactive Molecules

, 2018
Background: Living organisms are a natural source of ?-amino acids and peptides containing them. Many marine organisms and plants are able to produce by themselves such compounds, e.g.
Ramazan Ceylan, Gokhan Zengin, Ceylan, Ramazan, UYSAL, ŞENGÜL, Stefanucci, A., Sengul Uysal, ZENGİN, GÖKHAN, Azzurra Stefanucci, Stefanucci, Azzurra   +8 more
core   +1 more source

An acidic morpholine derivative containing glyceride from thraustochytrid, Aurantiochytrium

Scientific Reports, 2021
A novel acidic morpholine-derivative containing glyceride (M-glyceride) was isolated from the cells of two strains of the thraustochytrid, Aurantiochytrium. The glyceride accounted for approximately 0.1 -0.4% of the lyophilized cells.
Kunimitsu Kaya, Fujio Shiraishi, Tetsuo Iida, Masaki Yamada, Tomoharu Sano   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multilayer nanocapsules as a vehicle for release of bioactive compounds

, 2016
[Excerpt] Introduction: In the modern lifestyle, food is not intended only to satisfy hunger and provide necessary nutrients to humans, but it is also oriented to prevent nutrition-related diseases and increase physical and mental well-being of ...
Bourbon, Ana Isabel Juncá Sottomayor Lisboa, Silva, Hélder D., Vicente, A. A., Martins, Joana, Pinheiro, Ana Cristina   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source