Results 61 to 70 of about 90,186 (160)

Increased cAMP-PKA signaling pathway activation is involved in up-regulation of CTLA-4 expression in CD4+ T cells in acute SIVmac239-infected Chinese rhesus macaques

open access: yesVirus Research
Human immunodeficiency virus-1 (HIV-1) infection can cause chronic activation, exhaustion, and anergy of the immune system. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immune checkpoint molecule, which plays an important role in immune ...
Ren-Rong Tian   +4 more
doaj   +1 more source

Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART

open access: yesImmunity & Ageing
Background Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. Despite receiving HAART, immune reconstitution is not fully optimized.
Na Li   +9 more
doaj   +1 more source

Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy

open access: yesBMC Infectious Diseases
Background Achieving complete immune reconstitution (CIR) in people living with human immunodeficiency virus (PLWH) following antiretroviral therapy (ART) is essential for preventing acquired immunodeficiency syndrome (AIDS) progression and improving ...
Na Li   +10 more
doaj   +1 more source

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