Results 81 to 90 of about 1,531,106 (344)

Water‐Compatible SuFEx‐Active Diazonium Linchpin Platform for Rapid Modular Diversification and On‐DNA Functionalization

Advanced Functional Materials, EarlyView.
Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong, Dong Hyeon Kim, Yujin Lim, Yongseok Kwon, Sangkyu Lee, Han Yong Bae   +5 more
wiley   +1 more source

Bioactive peptides on endothelial function

, 2016
Cardiovascular diseases (CVD) such as myocardial infarction and stroke are a major cause of morbidity and mortality worldwide. Impairment of the normal vasorelaxant functions of the vascular endothelium, termed endothelial dysfunction; appear to underlie
Wu, Jianping, Chakrabarti, Subhadeep
core   +1 more source

Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech Poecilobdella manillensis

Toxins, 2018
Antistasin, first identified as a potent inhibitor of the blood coagulation factor Xa, is a novel family of serine protease inhibitors. In this study, we purified a novel antistasin-type inhibitor from leech Poecilobdella manillensis called poecistasin ...
Xiaopeng Tang, Mengrou Chen, Zilei Duan, James Mwangi, Pengpeng Li, Ren Lai   +5 more
doaj   +1 more source

Double‐Interpenetrating Composite Bioink for Multi‐Component 3D Bioprinting and Biofabrication

Advanced Functional Materials, EarlyView.
Marine‐polysaccharides‐derived double interpenetrating network hydrogel‐based bioink, combining the attributes of physical and ionic crosslinking, enables room‐temperature bioprinting of mechanically defined structures that can be handled and are cytocompatible.
Fabian Tribukait‐Riemenschneider, V. Prasad Shastri   +1 more
wiley   +1 more source

Natural Occurring β-Peptides: A Fascinating World of Bioactive Molecules

, 2018
Background: Living organisms are a natural source of ?-amino acids and peptides containing them. Many marine organisms and plants are able to produce by themselves such compounds, e.g.
Ramazan Ceylan, Gokhan Zengin, Ceylan, Ramazan, UYSAL, ŞENGÜL, Stefanucci, A., Sengul Uysal, ZENGİN, GÖKHAN, Azzurra Stefanucci, Stefanucci, Azzurra   +8 more
core   +1 more source

Peptide-Based Soft Hydrogels Modified with Gadolinium Complexes as MRI Contrast Agents

Pharmaceuticals, 2020
Poly-aromatic peptide sequences are able to self-assemble into a variety of supramolecular aggregates such as fibers, hydrogels, and tree-like multi-branched nanostructures.
Enrico Gallo, Carlo Diaferia, Enza Di Gregorio, Giancarlo Morelli, Eliana Gianolio, Antonella Accardo   +5 more
doaj   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Food-derived bioactive peptides on inflammation and oxidative stress

, 2014
Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions.
Wu, Jianping, Jahandideh, Forough, Chakrabarti, Subhadeep   +2 more
core   +1 more source

Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications

Scientific Reports
Dexamethasone (DEX) is a synthetic analogue of cortisol commonly used for the treatment of different pathological conditions, comprising cancer, ocular disorders, and COVID-19 infection.
Enrico Gallo, Carlo Diaferia, Giovanni Smaldone, Elisabetta Rosa, Giovanni Pecoraro, Giancarlo Morelli, Antonella Accardo   +6 more
doaj   +1 more source

T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

Journal for ImmunoTherapy of Cancer, 2019
Background Traditional therapies fail to cure most glioblastoma patients and the 5-year survival rate is less than 10%, highlighting need for new therapeutic approaches.
Dong Yang, Bin Sun, Hongjiu Dai, Wenxuan Li, Lan Shi, Peixian Zhang, Shirong Li, Xudong Zhao   +7 more
doaj   +1 more source