Results 41 to 50 of about 90,186 (160)
Toxins, 2020 Snake venoms contain components selected to immobilize prey. The venoms from Elapidae mainly contain neurotoxins, which are critical for rapid prey paralysis, while the venoms from Viperidae and Colubridae may contain fewer neurotoxins but are likely to ...
Huiwen Tian +9 more
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Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin
Scientific Reports, 2017 Very recently we proposed novel di- and tetra-phenylalanine peptides derivatized with gadolinium complexes as potentials supramolecular diagnostic agents for applications in MRI (Magnetic Resonance Imaging).
Carlo Diaferia +9 more
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Novel Sodium Channel Inhibitor From Leeches
Frontiers in Pharmacology, 2018 Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function
Gan Wang +16 more
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Bioactive peptides for anticancer therapies.
Biomaterials translational, 2023 Cancer is a serious concern in public health worldwide. Numerous modalities including surgery, radiotherapy, and chemotherapy, have been used for cancer therapies in clinic. Despite progress in anticancer therapies, the usage of these methods for cancer treatment is often related to deleterious side effects and multidrug resistance of conventional ...
Zhang, Yehao +3 more
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Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition
Scientific Reports, 2021 Ghrelin, a circulating orexigenic hormone secreted from the stomach, stimulates appetite and food intake by activating the hypothalamic arcuate nucleus. Administration of exogenous ghrelin exerts anabolic effects, causing weight gain, increased adiposity,
Takahiro Sato +6 more
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Molecular basis for heat desensitization of TRPV1 ion channels
Nature Communications, 2019 The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of ...
Lei Luo +8 more
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Bioactive Milk Peptides: A Prospectus
Journal of Dairy Science, 2000 Bioactive peptides have been identified within the amino acid sequences of native milk proteins. Hydrolytic reactions, such as those catalyzed by digestive enzymes, result in their release. These peptides directly influence numerous biological processes evoking behavioral, gastrointestinal, hormonal, immunological, neurological, and nutritional ...
D A, Clare, H E, Swaisgood
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Frontiers in Immunology, 2018 The northern pig-tailed macaques (NPMs) lack TRIM5α, an antiviral restriction factor, and instead have TRIM5-CypA. In our previous study, we demonstrated that HIV-1NL4−3 successfully infected NPMs and formed a long-term viral reservoir in vivo.
Wei Pang +10 more
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Emerging Microbes and InfectionsSimian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infections in nonhuman primates closely approximate human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), but intrinsic viral differences limit ...
Tian-Zhang Song +5 more
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Molecules, 2017 APOBEC3G is a member of the human cytidine deaminase family that restricts Vif-deficient viruses by being packaged with progeny virions and inducing the G to A mutation during the synthesis of HIV-1 viral DNA when the progeny virus infects new cells. HIV-
Huan Chen +6 more
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