Results 31 to 40 of about 90,186 (160)

Selection of experimental animals and modeling methods in developmental dysplasia of the hip research

EFORT Open Reviews
Developmental dysplasia of the hip (DDH) is a common neonatal musculoskeletal condition characterized by hip instability and inadequate acetabular coverage. If untreated, it can lead to osteoarthritis, chronic pain, and eventual hip replacement.
Yu Rao, Gonzalo Saiz-Gonzalo, Prateeksha Prateeksha, Anmin Wang, Hongxin Shi, Weiguo Wang, Chuan Li   +6 more
doaj   +1 more source

Correction to: ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

Virology Journal, 2019
In the original publication of this article [1], two grants from National Science Foundation of China and Yunnan Provincial Government (U1602226) and by National Science Foundation of China (2016YFC1200404) were omitted in the ‘Funding’ section.
Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang, Jumin Zhou   +6 more
doaj   +1 more source

ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

Virology Journal, 2017
Background The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcriptome of ZIKV ...
Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang, Jumin Zhou   +6 more
doaj   +1 more source

Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study

Scientific Reports
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents (e.g.
Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +6 more
doaj   +1 more source

Author Correction: Molecular basis for heat desensitization of TRPV1 ion channels

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Lei Luo, Yunfei Wang, Bowen Li, Lizhen Xu, Peter Muiruri Kamau, Jie Zheng, Fan Yang, Shilong Yang, Ren Lai   +8 more
doaj   +1 more source

Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech Poecilobdella manillensis

Toxins, 2018
Antistasin, first identified as a potent inhibitor of the blood coagulation factor Xa, is a novel family of serine protease inhibitors. In this study, we purified a novel antistasin-type inhibitor from leech Poecilobdella manillensis called poecistasin ...
Xiaopeng Tang, Mengrou Chen, Zilei Duan, James Mwangi, Pengpeng Li, Ren Lai   +5 more
doaj   +1 more source

Rigid Linkers for Bioactive Peptides [PDF]

Bioconjugate Chemistry, 2006
Rigid linkers of variable length were used to connect two high-affinity Nle4-D-Phe7-alpha-melanocyte stimulating hormone (NDP-alpha-MSH) or two low-affinity MSH(4) ligands. The linked peptides were synthesized by solid-phase methods. Control experiments indicate there is little or no effect of these linkers on NDP-alpha-MSH or MSH(4) binding to the ...
Josef, Vagner, Heather L, Handl, Yasunari, Monguchi, Umasish, Jana, Lucinda J, Begay, Eugene A, Mash, Victor J, Hruby, Robert J, Gillies   +7 more
openaire   +2 more sources

Peptide-Based Soft Hydrogels Modified with Gadolinium Complexes as MRI Contrast Agents

Pharmaceuticals, 2020
Poly-aromatic peptide sequences are able to self-assemble into a variety of supramolecular aggregates such as fibers, hydrogels, and tree-like multi-branched nanostructures.
Enrico Gallo, Carlo Diaferia, Enza Di Gregorio, Giancarlo Morelli, Eliana Gianolio, Antonella Accardo   +5 more
doaj   +1 more source

Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications

Scientific Reports
Dexamethasone (DEX) is a synthetic analogue of cortisol commonly used for the treatment of different pathological conditions, comprising cancer, ocular disorders, and COVID-19 infection.
Enrico Gallo, Carlo Diaferia, Giovanni Smaldone, Elisabetta Rosa, Giovanni Pecoraro, Giancarlo Morelli, Antonella Accardo   +6 more
doaj   +1 more source

T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells

Journal for ImmunoTherapy of Cancer, 2019
Background Traditional therapies fail to cure most glioblastoma patients and the 5-year survival rate is less than 10%, highlighting need for new therapeutic approaches.
Dong Yang, Bin Sun, Hongjiu Dai, Wenxuan Li, Lan Shi, Peixian Zhang, Shirong Li, Xudong Zhao   +7 more
doaj   +1 more source