Results 61 to 70 of about 197,269 (315)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Sustainable, functional food design: Characterizing and utilizing passion fruit by-product extract in anthocyanin-enriched delivery systems

Future Foods
This study evaluated various conditions, including ethanol concentration (60 to 80 %) and ultrasonic power (300 to 500 W), to determine the optimal ultrasound-assisted extraction (UAE) parameters for anthocyanins from purple passion fruit (Passiflora ...
Sopida Sakulrang, Mutasem Razem, Nima Mohammadi, Daniel Granato   +3 more
doaj   +1 more source

Detection and Quantification Methods for Viable but Non-culturable (VBNC) Cells in Process Wash Water of Fresh-Cut Produce: Industrial Validation

Frontiers in Microbiology, 2020
The significance of viable but non-culturable (VBNC) cells in the food industry is not well known, mainly because of the lack of suitable detection methodologies to distinguish them from dead cells.
Pilar Truchado, Maria I. Gil, Mar Larrosa, Ana Allende   +3 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Epigenetic and Genotoxic Mechanisms of PFAS-Induced Neurotoxicity: A Molecular and Transgenerational Perspective

Toxics
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants that continue to raise concern owing to their ability to accumulate in living organisms.
Narimane Kebieche, Seungae Yim, Claude Lambert, Rachid Soulimani   +3 more
doaj   +1 more source

BioAct-Het: A Heterogeneous Siamese Neural Network for Bioactivity Prediction Using Novel Bioactivity Representation

, 2023
Drug failure during experimental procedures due to low bioactivity presents a significant challenge. To mitigate this risk and enhance compound bioactivities, predicting bioactivity classes during lead optimization is essential.
Mehdi Paykan Heyrati (17394667), Zahra Ghorbanali (15195452), Fatemeh Zare-Mirakabad (525934), Mohammad Akbari (3564809), Ghasem Pishgahi (17394670)   +4 more
core   +1 more source

Ro5 Bioactivity Lab: Identification of Drug Candidates for COVID-19 [PDF]

, 2020
The public health emergency known as the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a large number of deaths worldwide and major socioeconomic disruption.
Žygimantas, Jočys, Roy, Tal, Zeyu, Yang, Mikhail, Demtchenko, Danius, Bačkis, Orestis, Bastas, Charles Dazler, Knuff, Aurimas, Pabrinkis, Cooper Stergis, Jamieson   +8 more
core   +1 more source

Metabolite profiling and bioactivity of Cicerbita alpina (L.) Wallr. (Asteraceae, Cichorieae) [PDF]

, 2023
Cicerbita alpina (L.) Wallr. is a perennial herbaceous plant in the tribe Cichorieae (Lactuceae), Asteraceae family, distributed in the mountainous regions in Europe. In this study, we focused on the metabolite profiling and the bioactivity of C.
Gokhan Zengin, Sinan, Kouadio Ibrahime, Alexandra Petrova, Olivier Joubert, Petrova, Alexandra, Joubert, Olivier, Dimitrina Zheleva-Dimitrova, Voynikov, Yulian, Kouadio Ibrahime Sinan, Simeonova, Rumyana, Yulian Voynikov, Gevrenova, Reneta, Rumyana Simeonova, Zengin, Gokhan, Reneta Gevrenova, Zidorn, Christian, Balabanova, Vessela, Zheleva-Dimitrova, Dimitrina, Christian Zidorn, Vessela Balabanova   +19 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source