Results 41 to 50 of about 389,785 (359)

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

EXCLI journal, 2011
EXCLI Journal ; Vol.
Kiatfuengfoo, Rachada, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Suksrichavalit, Thummaruk, Treeratanapiboon, Lertyot, Worachartcheewan, Apilak   +6 more
openaire   +3 more sources

Dual mechanisms of a purified root extract of Paeonia lactiflora Pall. in regulating uric acid homeostasis: inhibition of hepatic synthesis and promotion of renal excretion in hyperuricemic rat models

Frontiers in Pharmacology
IntroductionHyperuricemia (HUA), characterized by persistently elevated serum uric acid (UA), represents a growing global public-health concern. Current urate-lowering medications are often associated with hepatotoxicity and nephrotoxicity, highlighting ...
Tingting Jin, Ruoling Xu, Zhuoxin Jiang, Juncheng Ma, Ning Li   +4 more
doaj   +1 more source

Characterization and Isolation of Piperamides from Piper nigrum Cultivated in Costa Rica

Horticulturae, 2023
The piperamides profile of Piper nigrum cultivated in Costa Rica was studied using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight high-resolution mass spectrometry (UPLC-ESI-QTOF-HRMS) on enriched ...
Luis Felipe Vargas-Huertas, Luis Diego Alvarado-Corella, Andrés Sánchez-Kopper, Andrea Mariela Araya-Sibaja, Mirtha Navarro-Hoyos   +4 more
doaj   +1 more source

Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Fruits of Chaenomeles speciosa (Sweet) Nakai

Molecules
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) is a traditional Chinese herbal medicine that possesses not only abundant nutritional value but also significant medicinal properties. The extracts of C.
Kui Li, Ruoling Xu, Mengting Kuang, Wei Ma, Ning Li   +4 more
doaj   +1 more source

Mesoporous bioactive glass composition effects on degradation and bioactivity

Bioactive Materials, 2021
Mesoporous bioactive glasses (MBGs) are promising materials for regenerative medicine, due to their favorable properties including bioactivity and degradability. These key properties, but also their surface area, pore structure and pore volume are strongly dependent on synthesis parameters and glass stoichiometry.
Schumacher, M., Habibovic, P., van Rijt, S.   +2 more
openaire   +4 more sources

Bioactive glass engineered coatings for Ti6Al4V alloys: Influence of strontium substitution for calcium on sintering behaviour [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in JOURNAL OF NON-CRYSTALLINE SOLIDS. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Brauer, DS, Hill, RG, Lotfibakhshaiesh, N   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2 [PDF]

, 2014
The starfish SALMFamide neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide) are the prototypical members of a family of neuropeptides that act as muscle relaxants in echinoderms.
Adzhubei, Chassaing, Christopher E. Jones, Claire B. Otara, Edison, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Hewes, John H. Viles, Keire, Maurice R. Elphick, Melarange, Melarange, Nadine D. Younan, Nelson, Newman, Newman, Nieto, Otara, Pierson, Wegener, Xu   +25 more
core   +1 more source

Screening bioactivity and bioactive constituents of Nordic unifloral honeys [PDF]

Food Chemistry, 2017
The objective of this study was to screen the antibacterial and antioxidant activity of thirty nine honey samples from Finland, Sweden, Norway and Denmark. Their physicochemical properties were analysed, antioxidant activity was evaluated by DPPH assay and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus was assessed by ...
Tammela Päivi Sirpa Marjaana, Salonen Anneli, Fauch Laure Stephanie, Julkunen-Tiitto Riitta, Virjamo Virpi   +4 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source