Results 31 to 40 of about 197,269 (315)

High–Pressure Processing vs. Thermal Treatment: Effect on the Stability of Polyphenols in Strawberry and Apple Products

Foods, 2021
Polyphenols are important bioactive compounds that are affected by processing. The consumer’s demand for minimally processed products contributes to the increase in non-thermal technologies such as high-pressure processing (HPP) in the food industry ...
Gabriela Lorena Salazar-Orbea, Rocío García-Villalba, Francisco A. Tomás-Barberán, Luis Manuel Sánchez-Siles   +3 more
doaj   +1 more source

Leveraging molecular structure and bioactivity with chemical language models for drug design [PDF]

, 2021
Generative chemical language models (CLMs) can be used for de novo molecular structure generation. These CLMs learn from the structural information of known molecules to generate new ones.
Gisbert, Schneider, Michael, Moret, Francesca, Grisoni, Cyrill, Brunner   +3 more
core   +2 more sources

The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19

Frontiers in Pharmacology, 2021
Inflammasomes are large multimolecular complexes best recognized because of their ability to control activation of caspase-1, which in turn regulates the maturation of interleukin-18 (IL-18) and interleukin-1 β (IL-1β). IL-1β was originally identified as
Peng Li, Shuang Hu, Shuang Hu, Cheng Qian, Yan Yao, Yan Yao, Liang-yun Li, Liang-yun Li, Jun-fa Yang, Jun-fa Yang, Li Yang, Li Yang, Chen-chen Yang, Chen-chen Yang, Hong Zhou, Hong Zhou, Shu-xian Wang, Shu-xian Wang, Ying Hu, Ying Hu, Xing-yu Zhu, Jing Zhou, Jing Zhou, Lin-xin Pan, Chuan-pu Shen, Chuan-pu Shen, Huan Zhou   +26 more
doaj   +1 more source

Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats

Metabolites
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) fruit has medicinal and food applications and exhibits beneficial pharmacological properties. This study aimed to explore the hypouricemic effect of C.
Ruoling Xu, Peng Deng, Yiren Ma, Kui Li, Fucai Ren, Ning Li   +5 more
doaj   +1 more source

Current Evidence on the Bioavailability of Food Bioactive Peptides

Molecules, 2020
Food protein-derived bioactive peptides are recognized as valuable ingredients of functional foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases.
Lourdes Amigo, Blanca Hernández-Ledesma
doaj   +1 more source

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria

, 2019
Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of “silent” biosynthetic gene clusters (BGCs). These BGCs can be identified bioinformatically but are sparingly expressed under normal laboratory growth ...
Fei Xu, Chen Zhang (66790), Mohammad R. Seyedsayamdost (129142), Kyuho Moon (1426063), Chen Zhang, Mohammad R. Seyedsayamdost, Fei Xu (368913), Kyuho Moon   +7 more
core   +1 more source

Norlignans and Phenolics from Curculigo capitulata and Their Neuroprotection Against Glutamate-Induced Oxidative Injury in SH-SY5Y Cells

Molecules
The herb Curculigo capitulata (Lour.) Ktze is widely distributed in southern and southwestern China. The Curculigo genus and its primary chemical constituents exhibit remarkable antidepressant activities.
Xueru Wang, Wei Ma, Ying Wang, Fucai Ren, Kaijin Wang, Ning Li   +5 more
doaj   +1 more source

Modifiable Innate Biology within the Gut–Brain Axis for Alzheimer’s Disease

Biomedicines, 2022
Alzheimer’s disease (AD) is a prototypical inflammation-associated loss of cognitive function, with approximately 90% of the AD burden associated with invading myeloid cells controlling the function of the resident microglia.
Helena Marcos Pasero, Aurora García Tejedor, Juan Antonio Giménez-Bastida, José Moisés Laparra Llopis   +3 more
doaj   +1 more source

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

, 2018
It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification.
Julien Paolini (1502854), Pieter Leyssen (709993), Zheng Zhang (88857), Mélissa Nothias-Esposito (4906570), Pieter C. Dorrestein (224907), Ricardo da Silva (4906567), Theodore Alexandrov (1875955), Louis-Félix Nothias (3236412), David Touboul (116865), Jean Costa (1502848), Marc Litaudon (523316), Mingxun Wang (1327497), Ivan Protsyuk (3236406), Abi Sarvepalli (4906564)   +13 more
core   +1 more source

Dual mechanisms of a purified root extract of Paeonia lactiflora Pall. in regulating uric acid homeostasis: inhibition of hepatic synthesis and promotion of renal excretion in hyperuricemic rat models

Frontiers in Pharmacology
IntroductionHyperuricemia (HUA), characterized by persistently elevated serum uric acid (UA), represents a growing global public-health concern. Current urate-lowering medications are often associated with hepatotoxicity and nephrotoxicity, highlighting ...
Tingting Jin, Ruoling Xu, Zhuoxin Jiang, Juncheng Ma, Ning Li   +4 more
doaj   +1 more source