Results 31 to 40 of about 174,581 (217)

Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria

, 2019
Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of “silent” biosynthetic gene clusters (BGCs). These BGCs can be identified bioinformatically but are sparingly expressed under normal laboratory growth ...
Fei Xu, Chen Zhang (66790), Mohammad R. Seyedsayamdost (129142), Kyuho Moon (1426063), Chen Zhang, Mohammad R. Seyedsayamdost, Fei Xu (368913), Kyuho Moon   +7 more
core   +1 more source

Bioactivity in silica/poly(γ-glutamic acid) sol–gel hybrids through calcium chelation [PDF]

, 2013
Bioactive glasses and inorganic/organic hybrids have great potential as biomedical implant materials. Sol–gel hybrids with interpenetrating networks of silica and biodegradable polymers can combine the bioactive properties of a glass with the toughness ...
Romer, Frederik, Jones, Julian R., Wang, Daming, McPhail, David S., Smith, Mark E., Valliant, Esther M., Hanna, John V.   +6 more
core   +1 more source

Norlignans and Phenolics from Curculigo capitulata and Their Neuroprotection Against Glutamate-Induced Oxidative Injury in SH-SY5Y Cells

Molecules
The herb Curculigo capitulata (Lour.) Ktze is widely distributed in southern and southwestern China. The Curculigo genus and its primary chemical constituents exhibit remarkable antidepressant activities.
Xueru Wang, Wei Ma, Ying Wang, Fucai Ren, Kaijin Wang, Ning Li   +5 more
doaj   +1 more source

Modifiable Innate Biology within the Gut–Brain Axis for Alzheimer’s Disease

Biomedicines, 2022
Alzheimer’s disease (AD) is a prototypical inflammation-associated loss of cognitive function, with approximately 90% of the AD burden associated with invading myeloid cells controlling the function of the resident microglia.
Helena Marcos Pasero, Aurora García Tejedor, Juan Antonio Giménez-Bastida, José Moisés Laparra Llopis   +3 more
doaj   +1 more source

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

, 2018
It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification.
Julien Paolini (1502854), Pieter Leyssen (709993), Zheng Zhang (88857), Mélissa Nothias-Esposito (4906570), Pieter C. Dorrestein (224907), Ricardo da Silva (4906567), Theodore Alexandrov (1875955), Louis-Félix Nothias (3236412), David Touboul (116865), Jean Costa (1502848), Marc Litaudon (523316), Mingxun Wang (1327497), Ivan Protsyuk (3236406), Abi Sarvepalli (4906564)   +13 more
core   +1 more source

Stevia vs. Sucrose: Influence on the Phytochemical Content of a Citrus–Maqui Beverage—A Shelf Life Study

Foods, 2020
The consumption of sugar-sweetened beverages has been related with the risk of cardiovascular diseases and other pathophysiological situations, such as obesity or diabetes mellitus.
Francisco J. Salar, Vicente Agulló, Cristina García-Viguera, Raúl Domínguez-Perles   +3 more
doaj   +1 more source

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

EXCLI journal, 2011
EXCLI Journal ; Vol.
Kiatfuengfoo, Rachada, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Suksrichavalit, Thummaruk, Treeratanapiboon, Lertyot, Worachartcheewan, Apilak   +6 more
openaire   +3 more sources

Dual mechanisms of a purified root extract of Paeonia lactiflora Pall. in regulating uric acid homeostasis: inhibition of hepatic synthesis and promotion of renal excretion in hyperuricemic rat models

Frontiers in Pharmacology
IntroductionHyperuricemia (HUA), characterized by persistently elevated serum uric acid (UA), represents a growing global public-health concern. Current urate-lowering medications are often associated with hepatotoxicity and nephrotoxicity, highlighting ...
Tingting Jin, Ruoling Xu, Zhuoxin Jiang, Juncheng Ma, Ning Li   +4 more
doaj   +1 more source

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

, 2023
Covering: marine indole alkaloids (n = 2048) and their reported bioactivities up to the end of 2021 Despite increasing numbers of marine natural products (MNPs) reported each year, most have only been examined for cytotoxic, antibacterial, and/or ...
Darren C. Holland, Anthony R. Carroll, Carroll, Anthony R, Holland, Darren C   +3 more
core   +1 more source

Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Fruits of Chaenomeles speciosa (Sweet) Nakai

Molecules
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) is a traditional Chinese herbal medicine that possesses not only abundant nutritional value but also significant medicinal properties. The extracts of C.
Kui Li, Ruoling Xu, Mengting Kuang, Wei Ma, Ning Li   +4 more
doaj   +1 more source