Results 1 to 10 of about 582,498 (279)

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

open access: yesFrontiers in Pharmacology, 2022
Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma
Yahdiana Harahap   +3 more
doaj   +1 more source

Determination of O6-Methylguanine in dried blood spot of breast cancer patients after cyclophosphamide administration

open access: yesHeliyon, 2021
Cyclophosphamide is a nitrogen mustard class of drugs that are often used in cancer chemotherapy. However, the use of Cyclophosphamide in high doses over a long period has been shown to increase the risk of developing secondary cancer.
Yahdiana Harahap   +4 more
doaj   +1 more source

Folate Bioavailability [PDF]

open access: yesProceedings of the Nutrition Society, 2004
The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid.
Helene, McNulty, Kristina, Pentieva
openaire   +2 more sources

Effect of Ginger on Inflammatory Diseases

open access: yesMolecules, 2022
Ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation.
Pura Ballester   +5 more
doaj   +1 more source

Busulfan bioavailability [PDF]

open access: yesBlood, 1994
Busulfan is widely used as a component of the myeloablative therapy in bone marrow transplantation. Recent studies have shown that the drug disposition is altered in children and is associated with less therapeutic effectiveness, lower toxicities, and higher rates of engraftment failure.
M, Hassan   +8 more
openaire   +3 more sources

Carbohydrate bioavailability [PDF]

open access: yesBritish Journal of Nutrition, 2005
There is consensus that carbohydrate foods, in the form of fruit, vegetables and whole-grain products, are beneficial to health. However, there are strong indications that highly processed, fibre-depleted, and consequently rapidly digestible, energy-dense carbohydrate food products can lead to over-consumption and obesity-related diseases.
Klaus N, Englyst, Hans N, Englyst
openaire   +2 more sources

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement [PDF]

open access: yesNutrients, 2013
Flavonoids are a group of phytochemicals that have shown numerous health effects and have therefore been studied extensively. Of the six common food flavonoid classes, flavonols are distributed ubiquitously among different plant foods whereas appreciable amounts of isoflavones are found in leguminous plant-based foods.
Surangi Thilakarathna, H. Rupasinghe
openaire   +2 more sources

A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

open access: yesBIO Integration, 2021
The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences.
Muhammad Arif Asghar   +4 more
doaj   +1 more source

Research Note: Effects of organic zinc on broiler intestinal permeability and integrity in Clostridium perfringens–challenged condition

open access: yesPoultry Science, 2020
This study evaluates the effects of a zinc–amino acid complex on broiler's intestinal permeability and integrity challenged with Clostridium perfringens.
Jingjing Sun, Cheng Zhang, Bingkun Zhang
doaj   +1 more source

Complete dataset for 2-treatment, 2-sequence, 2-period efavirenz bioequivalence study conducted with nightly dosing

open access: yesData in Brief, 2016
The efavirenz pharmacokinetic raw data presented in this article was obtained in an average bioequivalence study between a local brand and Stocrin (Merck Sharp & Dohme, purchased from Australia, batch H009175, expiration date November 2013).
Manuel Ibarra   +4 more
doaj   +1 more source

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