Results 1 to 10 of about 469,546 (342)

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

Frontiers in Pharmacology, 2022
Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma
Yahdiana Harahap, Yahdiana Harahap, Steven Steven, Herman Suryadi   +3 more
doaj   +1 more source

Effect of Ginger on Inflammatory Diseases

Molecules, 2022
Ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation.
Pura Ballester, Begoña Cerdá, Raúl Arcusa, Javier Marhuenda, Karen Yamedjeu, Pilar Zafrilla   +5 more
doaj   +1 more source

A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

BIO Integration, 2021
The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences.
Muhammad Arif Asghar, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Muhammad Asif Asghar, Nazish Mumtaz   +4 more
doaj   +1 more source

A Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry Quantitative Method for Determination of Baricitinib in Plasma, and Its Application in a Pharmacokinetic Study in Rats

Molecules, 2020
Baricitinib, is a selective and reversible Janus kinase inhibitor, is commonly used to treat adult patients with moderately to severely active rheumatoid arthritis (RA).
Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Azza A Ali, Prawez Alam, Toqa El-Nahhas   +5 more
doaj   +1 more source

Validated Reversed-Phase Liquid Chromatographic Method with Gradient Elution for Simultaneous Determination of the Antiviral Agents: Sofosbuvir, Ledipasvir, Daclatasvir, and Simeprevir in Their Dosage Forms

Molecules, 2020
A simple, rapid, sensitive, and precise reversed-phase liquid chromatographic method was developed and validated for the simultaneous determination of four direct-acting antivirals, sofosbuvir (SF), ledipasvir (LD), declatasvir (DC), and simeprevir (SM),
Essam Ezzeldin, Nisreen F. Abo-Talib, Marwa H. Tammam, Yousif A. Asiri, Abd El-Galil E. Amr, Abdulrahman A. Almehizia   +5 more
doaj   +1 more source

Determination of isotretinoin in human plasma: Application to pharmacokinetic study

Bulletin of Faculty of Pharmacy Cairo University, 2012
A simple, rapid, sensitive and accurate HPLC–UV detection method was developed and validated for the determination of isotretinoin in human plasma. The method involves protein precipitation of plasma by acetonitrile using nifedipine as the internal ...
Nisreen F. Abo-Talib, Marwa H. Tammam, Essam E. Hassan   +2 more
doaj   +1 more source

Immobilization and assessment of heavy metals in chicken manure compost amended with rice straw-derived biochar

Environmental Pollutants & Bioavailability, 2021
In this study, a 30-days laboratory experiment was implemented to investigate the impact of additive biochar on the stabilization of heavy metals in chicken manure compost.
Hui Li, Wei Wu, Xue Min, Wenyong Zhan, Ting Fang, Xinju Dong, Yanhong Shi   +6 more
doaj   +1 more source

Determination of O6-Methylguanine in dried blood spot of breast cancer patients after cyclophosphamide administration

Heliyon, 2021
Cyclophosphamide is a nitrogen mustard class of drugs that are often used in cancer chemotherapy. However, the use of Cyclophosphamide in high doses over a long period has been shown to increase the risk of developing secondary cancer.
Yahdiana Harahap, Athalia Theda Tanujaya, Farhan Nurahman, Aurelia Maria Vianney, Denni Joko Purwanto   +4 more
doaj  

Assessment of high fluoride in water sources and endemic fluorosis in the North-Eastern communities of Gombe State, Nigeria

Environmental Pollutants & Bioavailability, 2021
Fluoride content of drinking water sources in 12 communities in North-Eastern states, Nigeria, was investigation. The fluoride concentration analyses were performed using the SPADNS method according to the standard method for examining water and ...
Abdulmoseen Segun Giwa, Abdul Ghaffar Memon, Jabran Ahmad, Tariq Ismail, Sikandar Ali Abbasi, Kashif Kamran, Baozhen Wang, Bamidele Segun, Hankouraou Seydou   +8 more
doaj   +1 more source

Dynamic analysis of platinum material flows and stocks with hybrid MFA method aiming to carbon neutral targets of automotive industry in China

Environmental Pollutants & Bioavailability, 2021
Platinum is a key material in the automotive industry. In this study, we first quantitatively analyzed the platinum cycle from 2009 to 2019 in the automotive industry in China.
Yana Zhang, Yingying Liu, He Lv, Sha Chen, Sumei Li   +4 more
doaj   +1 more source