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Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma
Yahdiana Harahap+3 more
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Bioavailability of carotenoids [PDF]
Abstract
Castenmiller, J.J.M., West, C.E.
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$β$-Carotene bioavailability and conversion efficiency are significantly affected by sex in rats. First observation suggesting a possible hormetic regulation of vitamin A metabolism in female rats [PDF]
Scope: To study the effect of variation in dietary vitamin A (VA) content on its hepatic and intestinal metabolism. Methods and results: Adult female and male rats were fed with diets containing 400, 2300, or 9858 IU/kg VA for 31-33 weeks. VA concentrations were measured in plasma and liver.
arxiv +1 more source
Flavonoid Bioavailability and Attempts for Bioavailability Enhancement [PDF]
Flavonoids are a group of phytochemicals that have shown numerous health effects and have therefore been studied extensively. Of the six common food flavonoid classes, flavonols are distributed ubiquitously among different plant foods whereas appreciable amounts of isoflavones are found in leguminous plant-based foods.
Surangi Thilakarathna, H. Rupasinghe
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Effect of Ginger on Inflammatory Diseases
Ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation.
Pura Ballester+5 more
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The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid.
Helene, McNulty, Kristina, Pentieva
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The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences.
Muhammad Arif Asghar+4 more
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Recent Trend of Nanotechnology Applications to Improve Bio-accessibility of Lycopene by Nanocarrier: A Review [PDF]
Lycopene, rich in red, yellow, or orange-colored fruits and vegetables, is the most potent antioxidant among the other carotenoids available in human blood plasma. It is evident that regular lycopene intake can prevent chronic diseases like cardiovascular diseases, type-2 diabetes, hypertension, kidney diseases and cancer.
arxiv +1 more source
Gap analysis of nickel bioaccessibility and bioavailability in different food matrices and its impact on the nickel exposure assessment [PDF]
The metal nickel is well known to cause nickel allergy in sensitive humans by prolonged dermal contact to materials releasing (high) amounts of nickel. Oral nickel exposure via water and food intake is of potential concern.
Babaahmadifooladi, Mehrnoosh+3 more
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Baricitinib, is a selective and reversible Janus kinase inhibitor, is commonly used to treat adult patients with moderately to severely active rheumatoid arthritis (RA).
Essam Ezzeldin+5 more
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