Results 1 to 10 of about 719,874 (416)

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

open access: yesFrontiers in Pharmacology, 2022
Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma
Yahdiana Harahap   +3 more
doaj   +1 more source

$β$-Carotene bioavailability and conversion efficiency are significantly affected by sex in rats. First observation suggesting a possible hormetic regulation of vitamin A metabolism in female rats [PDF]

open access: yesMolecular Nutrition and Food Research, Wiley-VCH Verlag, 2021, pp.2100650, 2021
Scope: To study the effect of variation in dietary vitamin A (VA) content on its hepatic and intestinal metabolism. Methods and results: Adult female and male rats were fed with diets containing 400, 2300, or 9858 IU/kg VA for 31-33 weeks. VA concentrations were measured in plasma and liver.
arxiv   +1 more source

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement [PDF]

open access: yesNutrients, 2013
Flavonoids are a group of phytochemicals that have shown numerous health effects and have therefore been studied extensively. Of the six common food flavonoid classes, flavonols are distributed ubiquitously among different plant foods whereas appreciable amounts of isoflavones are found in leguminous plant-based foods.
Surangi Thilakarathna, H. Rupasinghe
openaire   +3 more sources

Effect of Ginger on Inflammatory Diseases

open access: yesMolecules, 2022
Ulcerative colitis, Crohn’s disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation.
Pura Ballester   +5 more
doaj   +1 more source

Folate Bioavailability [PDF]

open access: yesProceedings of the Nutrition Society, 2004
The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid.
Helene, McNulty, Kristina, Pentieva
openaire   +2 more sources

A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

open access: yesBIO Integration, 2021
The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences.
Muhammad Arif Asghar   +4 more
doaj   +1 more source

Recent Trend of Nanotechnology Applications to Improve Bio-accessibility of Lycopene by Nanocarrier: A Review [PDF]

open access: yesJournal of Food Chemistry and Nanotechnology 8(4): 162-180, 2022, 2023
Lycopene, rich in red, yellow, or orange-colored fruits and vegetables, is the most potent antioxidant among the other carotenoids available in human blood plasma. It is evident that regular lycopene intake can prevent chronic diseases like cardiovascular diseases, type-2 diabetes, hypertension, kidney diseases and cancer.
arxiv   +1 more source

Gap analysis of nickel bioaccessibility and bioavailability in different food matrices and its impact on the nickel exposure assessment [PDF]

open access: yes, 2020
The metal nickel is well known to cause nickel allergy in sensitive humans by prolonged dermal contact to materials releasing (high) amounts of nickel. Oral nickel exposure via water and food intake is of potential concern.
Babaahmadifooladi, Mehrnoosh   +3 more
core   +2 more sources

A Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry Quantitative Method for Determination of Baricitinib in Plasma, and Its Application in a Pharmacokinetic Study in Rats

open access: yesMolecules, 2020
Baricitinib, is a selective and reversible Janus kinase inhibitor, is commonly used to treat adult patients with moderately to severely active rheumatoid arthritis (RA).
Essam Ezzeldin   +5 more
doaj   +1 more source

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