Results 61 to 70 of about 719,874 (416)
Frontiers in PharmacologyPhenytoin is a first-line antiepileptic drug with narrow therapeutic range and follows non-linear pharmacokinetics. Pharmacokinetics of phenytoin have been studied in plasma matrix before, however, there were several disadvantages.
Yahdiana Harahap +3 more
doaj +1 more source
DiffHopp: A Graph Diffusion Model for Novel Drug Design via Scaffold Hopping [PDF]
arXiv, 2023 Scaffold hopping is a drug discovery strategy to generate new chemical entities by modifying the core structure, the \emph{scaffold}, of a known active compound. This approach preserves the essential molecular features of the original scaffold while introducing novel chemical elements or structural features to enhance potency, selectivity, or ...
arxiv
A method for improving Centre for Environmental Studies (CML) characterisation factors for metal (eco)toxicity - the case of zinc gutters and downpipes [PDF]
, 2010 Background, aim and scope - The environmental impact of building products made from heavy metals has been a topic of discussion for some years. This was fuelled by results of life cycle assessments (LCAs), where the emission of heavy metals strongly ...
Jongbloed, R.H. +2 more
core +2 more sources
Antioxidants, 2020 Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological ...
P. Cosme +3 more
semanticscholar +1 more source
, 2009 An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core
Antioxidants and Redox Signaling, 2013 Human intervention trials have provided evidence for protective effects of various (poly)phenol-rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer. While there are considerable data suggesting benefits of (
D. Del Rio +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Cyclosporine Absorption Following Orthotopic Liver Transplantation [PDF]
, 1986 Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption.
Beveridge +20 more
core +2 more sources
A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models [PDF]
, 2020 Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution.
Haase, Hajo, Maares, Maria
core +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source