Results 81 to 90 of about 582,498 (279)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Spatial and temporal trends in total organic carbon (TOC), black carbon (BC), and total nitrogen (TN) and their relationships under different planting patterns in a restored coastal mangrove wetland: case study in Fujian, China

Chemical Speciation & Bioavailability, 2018
This study aims to determine the sediment changes and the trends in TOC, BC and TN before and after restoration of the mangrove wetland in the Jinjiang Estuary and to determine the effect of the wetland restoration process on the biogeochemical cycle of ...
Peiyong Guo, Yinshi Sun, Haitao Su, Meixian Wang, Yuxuan Zhang   +4 more
doaj   +1 more source

Preliminary study of the distribution and risk assessment of mercury in different surficial sediments along the coastal area of the province Thai Binh in Vietnam

Environmental Pollutants & Bioavailability, 2020
Surficial sediment samples along the coastal area of the province Thai Binh in Vietnam have been collected and analysed by modified Tessier method for the mercury content.
Thi Lim Duong, Thi Lan Huong Nguyen, Thi Hue Nguyen, Thi Huong Thuy Nguyen, Thu Thuy Tran, Van Long Nguyen, Gabriele Walenzik, Wolfgang Genthe, Karl-Ulrich Rudolph, Ngo Nghia Pham, Ngoc Nhiem Dao   +10 more
doaj   +1 more source

Genetic programming in data mining for drug discovery [PDF]

, 2004
Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core   +2 more sources

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats [PDF]

, 2017
The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in ...
Beaudry, F, Benito, J, Doodnaught, G M, Edge, D, Monteiro, B P, Pelligand, L, Steagall, P   +6 more
core   +3 more sources

Reprogramming Tumor Cell Death via Processing Natural Drug to Carbon Dots Overcomes Collagen Barrier and Activates Antitumor Immunity

Advanced Functional Materials, EarlyView.
A traditional Chinese medicine‐derived carbon dots nanoplatform reprograms tumor cell death from apoptosis to necroptosis, dismantling therapy‐induced collagen barriers and promoting immunogenic death. pH‐responsive hydrogel assembled from carbon dots for localized delivery, this strategy suppresses primary tumors and metastasis, offering a new ...
Zekun Yan, Hongwei Cheng, Yupeng Liu, Wenfeng Xu, Quansheng Cheng, Lingyun Li, Xue Wu, Yingqi Liang, Jing Zhao, Gang Liu, Shaoping Li, Songnan Qu   +11 more
wiley   +1 more source

Spatial distribution of total halogenated organic compounds (TX), adsorbable organic halogens (AOX), and heavy metals in wetland soil irrigated with pulp and paper wastewater

Chemical Speciation & Bioavailability, 2017
Long-term irrigation using wastewater from paper industry may cause seriously problems to the receiving soil. This work surveyed and monitored the soil quality of a wastewater irrigation wetland system in Yancheng City, Jiangsu Province in China in 2014 ...
Liqiang Cui, Tianming Chen, Cheng Ding, Zhaoxia Li, Jinlong Yan, Yang Liu, Xian Niu, Aihui Chen, Wenjun Yang   +8 more
doaj   +1 more source

Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]

, 2012
Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T., Subramaniam, G., Lee, J., Loh, H.M., Leung, P.H.H.   +4 more
core   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling

Scientific Reports
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets.
Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui   +3 more
doaj   +1 more source