Rational Enzyme Engineering Through Biophysical and Biochemical Modeling [PDF]
, 2016 Due to its importance in the pharmaceutical industry, ligand dynamic simulations have experienced a great expansion. Using all-atom models and cutting edge hardware, one can perform non-biased ligand migration, active site search and binding studies.
Acebes, Sandra +8 more
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Systems Biology Graphical Notation: Activity Flow language Level 1 [PDF]
, 2009 Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace.
Anatoly Sorokin +4 more
core +2 more sources
Spotting priming-active compounds using parsley cell cultures in microtiter plates
BMC Plant Biology, 2023 Background Conventional crop protection has major drawbacks, such as developing pest and pathogen insensitivity to pesticides and low environmental compatibility. Therefore, alternative crop protection strategies are needed. One promising approach treats
Kyra Hoffmann +6 more
doaj +1 more source
Systems Biology Graphical Notation: Process Description language Level 1 [PDF]
, 2009 Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace.
Anatoly Sorokin +4 more
core +2 more sources
Scientific Reports, 2022 Bovine enterokinase light chain (EKL) is an industrially useful protease for accurate removal of affinity-purification tags from high-value biopharmaceuticals.
Weiluo Lee +6 more
doaj +1 more source
Improved split fluorescent proteins for endogenous protein labeling. [PDF]
, 2017 Self-complementing split fluorescent proteins (FPs) have been widely used for protein labeling, visualization of subcellular protein localization, and detection of cell-cell contact.
Feng, Siyu +5 more
core +2 more sources
Microbial Cell Factories, 2018 Background Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite repression, substrate inhibition or overflow metabolism.
P. Philip +6 more
doaj +1 more source
Highly efficient fermentation of 5-keto-d-fructose with Gluconobacter oxydans at different scales
Microbial Cell Factories, 2022 Background The global market for sweeteners is increasing, and the food industry is constantly looking for new low-caloric sweeteners. The natural sweetener 5-keto-d-fructose is one such candidate.
Svenja Battling +8 more
doaj +1 more source
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]
, 2019 Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana +15 more
core +2 more sources
Systematic evaluation of characteristics of the membrane-based fed-batch shake flask
Microbial Cell Factories, 2017 Background The initial part of process development involves extensive screening programs to identify optimal biological systems and cultivation conditions.
P. Philip +6 more
doaj +1 more source