Results 11 to 20 of about 66,620 (264)

In Vitro Membrane Remodeling by ESCRT is Regulated by Negative Feedback from Membrane Tension

iScience, 2019
Summary: Artificial cells can shed new light on the molecular basis for life and hold potential for new chemical technologies. Inspired by how nature dynamically regulates its membrane compartments, we aim to repurpose the endosomal sorting complex ...
Andrew Booth, Christopher J. Marklew, Barbara Ciani, Paul A. Beales   +3 more
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Origin of Life and Birth of Life ― An Open Access Journal

Life, 2011
Our publishing company MDPI (Multidisciplinary Digital Publishing Institute) planned to launch this journal Life (ISSN 2075-1729) since June 2009. Life science as a topic covers a very broad area.
Shu-Kun Lin
doaj   +1 more source

Met125 is essential for maintaining the structural integrity of calmodulin’s C-terminal domain

Scientific Reports, 2020
We have used NMR and circular dichroism spectroscopy to investigate the structural and dynamic effects of oxidation on calmodulin (CaM), using peroxide and the Met to Gln oximimetic mutations.
Sarah E. D. Nelson, Daniel K. Weber, Robyn T. Rebbeck, Razvan L. Cornea, Gianluigi Veglia, David D. Thomas   +5 more
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Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Communications Biology, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006 ...
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Sanford M. Simon, Susan S. Taylor, Gianluigi Veglia   +11 more
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Evaluation of variability in high-resolution protein structures by global distance scoring

Heliyon, 2018
Systematic analysis of the statistical and dynamical properties of proteins is critical to understanding cellular events. Extraction of biologically relevant information from a set of high-resolution structures is important because it can provide ...
Risa Anzai, Yoshiki Asami, Waka Inoue, Hina Ueno, Koya Yamada, Tetsuji Okada   +5 more
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Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis

Nature Communications, 2022
Bacterial hairs called pili become highly-conductive electric wires upon addition of both natural and synthetic amino acids conjugated with gold nanoparticles.
Daniel Mark Shapiro, Gunasheil Mandava, Sibel Ebru Yalcin, Pol Arranz-Gibert, Peter J. Dahl, Catharine Shipps, Yangqi Gu, Vishok Srikanth, Aldo I. Salazar-Morales, J. Patrick O’Brien, Koen Vanderschuren, Dennis Vu, Victor S. Batista, Nikhil S. Malvankar, Farren J. Isaacs   +14 more
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Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Communications Biology, 2021
Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity.
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia   +11 more
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Generalized Michaelis-Menten rate law with time-varying molecular concentrations.

PLoS Computational Biology, 2023
The Michaelis-Menten (MM) rate law has been the dominant paradigm of modeling biochemical rate processes for over a century with applications in biochemistry, biophysics, cell biology, systems biology, and chemical engineering.
Roktaek Lim, Thomas L P Martin, Junghun Chae, Woo Joong Kim, Cheol-Min Ghim, Pan-Jun Kim   +5 more
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Engineering multiple species-like genetic incompatibilities in insects

Nature Communications, 2020
Natural speciation can be driven by pre-zygotic and post-zygotic barriers. Here the authors use a dominant lethal transgene coupled to a recessive resistance allele to engineer species-like barriers in Drosophila.
Maciej Maselko, Nathan Feltman, Ambuj Upadhyay, Amanda Hayward, Siba Das, Nathan Myslicki, Aidan J. Peterson, Michael B. O’Connor, Michael J. Smanski   +8 more
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Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Heliyon, 2019
Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome ...
Karoline Sanches, Raphael Vinicius Rodrigues Dias, Paulo Henrique da Silva, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fátima Pereira de Souza, Leandro Cristante de Oliveira, Fernando Alves de Melo   +7 more
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