Results 21 to 30 of about 69,923 (265)
Heliyon, 2019 Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome ...
Karoline Sanches +7 more
doaj +1 more source
Redefining the role of AMPK in autophagy and the energy stress response
Nature Communications, 2023 Autophagy maintains cellular homeostasis during low energy states. According to the current understanding, glucose-depleted cells induce autophagy through AMPK, the primary energy-sensing kinase, to acquire energy for survival.
Ji-Man Park, Da-Hye Lee, Do-Hyung Kim
doaj +1 more source
Scientific Reports, 2022 Eukaryotes express a multi-component fatty acid elongase to produce very long chain fatty acids (VLCFAs), which are building blocks of diverse lipids.
Kenna E. Stenback +4 more
doaj +1 more source
Cells, 2020 We engineered a concatenated fluorescent biosensor and dual-wavelength fluorescence lifetime (FLT) detection, to perform high-throughput screening (HTS) in living cells for discovery of potential heart-failure drugs.
Tory M. Schaaf +7 more
doaj +1 more source
Scientific Reports, 2018 We have used electron paramagnetic resonance, with rigid and stereospecific spin labels, to resolve structural states in calmodulin (CaM), as affected by binding of Ca and a CaM-binding peptide (RyRp) derived from the ryanodine receptor (RyR), the Ca ...
Cheng Her +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
STAR Protocols, 2021 Summary: Inducible biomolecular condensates play fundamental roles in cellular responses to intracellular and environmental cues. Knowledge about their composition is crucial to understand the functions that arise specifically from the assembly of ...
Emile Alghoul +2 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae
Nature Communications, 2021 RNA polyadenosine tails are important for the export, translation and stability of mRNAs and play a role in non-coding RNA biogenesis. Here the authors measure yeast poly(A) tail lengths by direct RNA sequencing, revealing its dynamics in yeast ...
Agnieszka Tudek +7 more
doaj +1 more source
Ukrainian science in the context of its anticolonial struggle
BBA Advances, 2023 The current Special Issue entitled “Highlights of Ukrainian Molecular Biosciences” is dedicated to presenting recent contributions in the areas of biochemistry and biophysics, molecular biology and genetics, molecular and cellular physiology, and ...
Alexey S. Ladokhin
doaj +1 more source