Results 11 to 20 of about 956,419 (320)
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms. Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein.
Mandelkow, E., Mandelkow, E.
europepmc +6 more sources
Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology: Introduction to a Thematic Review Series. [PDF]
J Lipid Res, 2016 This article is available online at http://www.jlr.org Glycosylphosphatidylinositol (GPI) is a lipid anchor for many cell-surface proteins. The GPI anchor represents a posttranslational modifi cation of proteins with a glycolipid and is used ubiquitously
Kinoshita T.
europepmc +2 more sources
A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis [PDF]
Journal of Mammary Gland Biology and Neoplasia, 2021 AbstractLactose is the primary carbohydrate in the milk of most mammals and is unique in that it is only synthesized by epithelial cells in the mammary glands. Lactose is also essential for the development and nutrition of infants. Across species, the concentration of lactose in milk holds a strong positive correlation with overall milk volume ...
Anna Sadovnikova +2 more
openaire +5 more sources
The Biochemistry and Cell Biology of Embryo Storage Proteins [PDF]
, 1997 Seed legumes accumulate massive amounts of certain characteristic proteins. These include the 7S and US seed storage proteins, lectins and various 2S proteins. With the advent of molecular cloning techniques, a large and increasing number of primary structures of these proteins from many plants are available in the international databases.
Niels C. Nielsen +2 more
openaire +2 more sources
EFSA Journal, 2022 The utility of pesticides in the agricultural field is unquestionable, but at the same time pesticide use presents serious hazards to the environment and the human health.
Vasiliki Garefalaki +3 more
doaj +1 more source
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway.
Annual Review of Biochemistry, 2022 In the decade since the discovery of the innate immune cyclic GMP-AMP synthase (cGAS)- 2'3'-cyclic GMP-AMP (cGAMP)- stimulator of interferon genes (STING) pathway, its proper activation and dysregulation have been rapidly implicated in many aspects of ...
C. Ritchie +2 more
semanticscholar +1 more source
Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines
npj Vaccines, 2021 Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading pathogens through recognition of pathogen-associated molecular patterns.
Rossella Sartorius +4 more
doaj +1 more source
Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles
Scientific Reports, 2022 Repurposing FDA-approved drugs is an efficient and cost-effective approach in the development of therapeutics for a broad range of diseases. However, prediction of function can be challenging, especially in the brain. We screened a small-molecule library
Sara Tucker Edmister +7 more
doaj +1 more source
Nature Communications, 2022 The colonic mucus layer is an organized system providing a physical barrier against pathogens and simultaneously harbouring the commensal flora. Here the authors report that transglutaminase 3 activity contributes to homeostasis of the colonic mucus ...
Jack D. A. Sharpen +8 more
doaj +1 more source
Neural Plasticity, 2022 The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ageing
Stefano Farioli-Vecchioli +2 more
doaj +1 more source