Results 21 to 30 of about 956,419 (320)

An 8-cage imaging system for automated analyses of mouse behavior

open access: yesScientific Reports, 2023
The analysis of mouse behavior is used in biomedical research to study brain function in health and disease. Well-established rapid assays allow for high-throughput analyses of behavior but have several drawbacks, including measurements of daytime ...
Thaís Del Rosario Hernández   +4 more
doaj   +1 more source

Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations

open access: yesScientific Reports, 2023
More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding of how chemoresistant populations evolve over the course of EOC progression post chemotherapy ...
Carolina Mejia Peña   +5 more
doaj   +1 more source

Rachel Jacobson's Painful Hip

open access: yesMedEdPORTAL, 2009
This is a problem-based learning case for a medical biochemistry-molecular biology course suitable for first- or second-year medical students. The case is that of a young girl who is diagnosed as a compound heterozygote for Gaucher disease and is treated
Marshall Anderson
doaj   +1 more source

Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry

open access: yesMolecular Biology of the Cell, 2020
Most of the fascinating phenomena studied in cell biology emerge from interactions among highly organized multimolecular structures embedded into complex and frequently dynamic cellular morphologies.
Margaret E. Johnson   +9 more
semanticscholar   +1 more source

Peptides as multifunctional players in cancer therapy

open access: yesExperimental and Molecular Medicine, 2023
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have
Sri Murugan Poongkavithai Vadevoo   +7 more
doaj   +1 more source

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

open access: yesMolecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar   +5 more
doaj   +1 more source

Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice

open access: yesScientific Reports, 2022
miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard.
Dillon Shapiro   +3 more
doaj   +1 more source

Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury

open access: yesRespiratory Research, 2022
Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endothelial cell dysfunction drives this ...
Jason L. Chang   +7 more
doaj   +1 more source

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

open access: yesNature Communications, 2016
The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of theDrosophilafat body with roles in metabolism, immunological
Brian C. Jones   +6 more
doaj   +1 more source

The biochemical basis of disease [PDF]

open access: yes, 2018
Understanding Biochemistry is an essential online resource for post-16 students, teachers and undergraduates, providing up-to-date overviews of key concepts in biochemistry and molecular biosciences.
Ahlqvist   +52 more
core   +1 more source

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