Results 51 to 60 of about 1,093 (175)

Mixed Selectivity in Macaque Medial Parietal Cortex during Eye-Hand Reaching

iScience, 2020
Summary: The activity of neurons of the medial posterior parietal area V6A in macaque monkeys is modulated by many aspects of reach task. In the past, research was mostly focused on modulating the effect of single parameters upon the activity of V6A ...
Stefano Diomedi, Francesco E. Vaccari, Matteo Filippini, Patrizia Fattori, Claudio Galletti   +4 more
doaj   +1 more source

Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

iScience, 2022
Summary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM).
Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xisong Liang, Liyang Zhang, Yun Peng, Peng Luo, Jian Zhang, Zaoqu Liu, Quan Cheng, Zhixiong Liu   +12 more
doaj   +1 more source

Novel Techniques and Their Applications to Health Foods, Agricultural and Medical Biotechnology: Functional Genomics and Basic Epigenetic Controls in Plant and Animal Cells [PDF]

, 2004
Selected applications of novel techniques for analyzing Health Food formulations, as well as for advanced investigations in Agricultural and Medical Biotechnology aimed at defining the multiple connections between functional genomics and epigenomic ...
Baianu, I.C., Lin, H.C., Lozano, P., Prisecaru, V. I.   +3 more
core  

Graphical Modeling for High Dimensional Data [PDF]

, 2012
With advances in science and information technologies, many scientific fields are able to meet the challenges of managing and analyzing high-dimensional data.
Bagga, Jay, Begum, Munni, Blakey, C. Ann
core   +2 more sources

Синтез, протимікробна активність та докінгові дослідження 6-(1H-бензімідазол-2- іл)-5-метилтієно[2,3-d]піримідин-4(3H)-онів з ацетамідними та 1,2,4-оксадіазол-5- ілметильними замісниками [PDF]

, 2021
Aim. To synthesize, study the antimicrobial activity and suggest antimicrobial activity mechanism for the novel derivatives of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one. Results and discussion.
Borysov, Oleksandr V., Georgiyants, Victoriya A., Kovalenko, Sergiy M., Osolodchenko, Tetiana P., Severina, Hanna I., Vlasov, Sergiy V., Vlasov, Vitaliy S.   +6 more
core   +2 more sources

Electroactive Proteinoid–Quantum Dot Systems

Small Science, Volume 5, Issue 12, December 2025.
Proteinoid‐quantum dot conjugates form toroidal nanostructures (145.2 nm outer diameter, 102.3 nm cavity) via glutamic acid‐phenylalanine‐aspartic acid‐cysteine cross‐linking with sulfo‐SMCC (sulfosuccinimidyl 4‐(N‐maleimidomethyl)cyclohexane‐1‐carboxylate).
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

iScience
Summary: Toxicogenomic data provide key insights into molecular mechanisms underlying drug-induced organ toxicities. To simplify transcriptomic data interpretation, we applied weighted gene co-expression network analysis (WGCNA) to rat kidney ...
Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water   +16 more
doaj   +1 more source

KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface

iScience, 2020
Summary: RAS proteins function as highly regulated molecular switches that control cellular growth. In addition to regulatory proteins, RAS undergoes a number of posttranslational modifications (PTMs) that regulate its activity.
Guowei Yin, Jerry Zhang, Vinay Nair, Vinh Truong, Angelo Chaia, Johnny Petela, Joseph Harrison, Alemayehu A. Gorfe, Sharon L. Campbell   +8 more
doaj   +1 more source

miRSCAPE - inferring miRNA expression from scRNA-seq data

iScience, 2022
Summary: Our understanding of miRNA activity at cellular resolution is thwarted by the inability of standard scRNA-seq protocols to capture miRNAs. We introduce a novel tool, miRSCAPE, to infer miRNA expression in a sample from its RNA-seq profile.
Gulden Olgun, Vishaka Gopalan, Sridhar Hannenhalli   +2 more
doaj   +1 more source

Modeling foot sole cutaneous afferents: FootSim

iScience, 2023
Summary: While walking and maintaining balance, humans rely on cutaneous feedback from the foot sole. Electrophysiological recordings reveal how this tactile feedback is represented in neural afferent populations, but obtaining them is difficult and ...
Natalija Katic, Rodrigo Kazu Siqueira, Luke Cleland, Nicholas Strzalkowski, Leah Bent, Stanisa Raspopovic, Hannes Saal   +6 more
doaj   +1 more source