Results 11 to 20 of about 125,907 (238)

Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies [PDF]

Molecular Therapy - Methods & Clinical Development, 2018
Since the human genome decoding, understanding and identification of genetic disturbances behind many diseases, including cancer, are intensively increasing. Scientific and technological advances in this area trigger the search for therapeutic (curative) approaches targeting the correction of gene disturbances.
Beatriz Silva Lima, Mafalda Ascensão Videira   +1 more
openaire   +3 more sources

PLA Microparticles for Pulmonary Delivery of AntiTB drugs: Biodistribution study [PDF]

, 2008
A dry powder inhalable (DPI) microparticles comprising anti-tuberculosis drugs incorporated in biodegradable polymers was developed for the treatment of pulmonary tuberculosis (P. Muttil _et al_. 2007).
Amit Misra, Awadh Bihari Yadav, Jatinder Kaur, Kauslender Kumar, Rahul Kumar Verma   +4 more
core   +2 more sources

Biodistribution of therapeutic extracellular vesicles

Extracellular Vesicles and Circulating Nucleic Acids, 2023
The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to being considered essential mediators in intercellular communication. Their unique ability to transfer macromolecules across cells and biological barriers has made them a rising star in drug delivery ...
Gupta, Dhanu, Wiklander, Oscar P.B, Wood, Matthew J.A, El-Andaloussi, Samir   +3 more
openaire   +2 more sources

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

Unraveling the In Vivo Protein Corona

Cells, 2021
Understanding the behavior of nanoparticles upon contact with a physiological environment is of urgent need in order to improve their properties for a successful therapeutic application.
Johanna Simon, Gabor Kuhn, Michael Fichter, Stephan Gehring, Katharina Landfester, Volker Mailänder   +5 more
doaj   +1 more source

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography [PDF]

, 2008
The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor ...
Bergstr  m, Burns, Chou, D. A. Harki, D. B. Stout, Dervan, Dervan, Dudouet, Edelson, Gross, Harapanhalli, Hsu, K  hnast, Lee, Lendvai, M. E. Phelps, N. Satyamurthy, P. B. Dervan, Phelps, Phelps, Poethko, Puckett, Roivainen, Schottelius, Tavitian, Toyokuni, Trauger   +26 more
core   +3 more sources

Visualization of cardiac uptake of bone marrow mesenchymal stem cell‐derived extracellular vesicles after intramyocardial or intravenous injection in murine myocardial infarction

Physiological Reports, 2023
In animal models, human bone marrow mesenchymal stem cell‐derived extracellular vesicles (MSC‐EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection.
Cynthia M. Xu, Sharif A. Sabe, Rayane Brinck‐Teixeira, Mohamed Sabra, Frank W. Sellke, M. Ruhul Abid   +5 more
doaj   +1 more source

Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents [PDF]

, 2008
This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract
Adenilson de Souza da Fonseca, Benarroz M. O., Bernardo-Filho M., Capriles P. V., Claudia Leite Diniz, Danielle Santos de Almeida, Fernanda Santos do Carmo, Fonseca A. S., Frydman J. N. G., Goel H. C., Inamdar P. K., Jayashree G., Mario Bernardo Filho, Moreno S.R., Owunwanne A., Padma P. R., Rebello B. M., Saha G. B., Sebastião David Santos-Filho, Sharma J., Shobi V., Simões C. M. O., Sotiris Missailidis   +22 more
core   +4 more sources

Assessment of the biocompatibility and biodistribution of fluorescent oleic acid capped ZnSe/CdS/ core shell quantum dots after intravenous injection in Balb/c mice [PDF]

BioImpacts
Introduction: Quantum dots (QDs) are semiconductor nanocrystals with inherent fluorescence having several advantages over traditional fluorescent probes including their small size (5–10 nm), tunable excitation and emission spectra, ease of surface ...
Aakriti Tyagi, Disha Mittal, S. Bhanoth, Ankita Leekha, Anita K. Verma   +4 more
doaj   +1 more source

G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model [PDF]

, 2013
Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways.
Alonso, Silvia del Valle, Bichara, Darío Román, Chiaramoni, Nadia Silvia, del Rio Zabala, Nahuel Eduardo, Marotta, Cristian Hernán, Prieto, Maria Jimena, Simonetta, Sergio Hernan   +6 more
core   +2 more sources