Results 11 to 20 of about 63,325 (247)
Biodistribution of therapeutic extracellular vesicles
Extracellular Vesicles and Circulating Nucleic Acids, 2023 The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to being considered essential mediators in intercellular communication. Their unique ability to transfer macromolecules across cells and biological barriers has made them a rising star in drug delivery ...
Gupta, Dhanu +3 more
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Unraveling the In Vivo Protein Corona
Cells, 2021 Understanding the behavior of nanoparticles upon contact with a physiological environment is of urgent need in order to improve their properties for a successful therapeutic application.
Johanna Simon +5 more
doaj +1 more source
Physiological Reports, 2023 In animal models, human bone marrow mesenchymal stem cell‐derived extracellular vesicles (MSC‐EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection.
Cynthia M. Xu +5 more
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Assessment of the biocompatibility and biodistribution of fluorescent oleic acid capped ZnSe/CdS/ core shell quantum dots after intravenous injection in Balb/c mice [PDF]
BioImpactsIntroduction: Quantum dots (QDs) are semiconductor nanocrystals with inherent fluorescence having several advantages over traditional fluorescent probes including their small size (5–10 nm), tunable excitation and emission spectra, ease of surface ...
Aakriti Tyagi +4 more
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Nanomaterials, 2020 A better understanding of the impact of molecular size and linkers is important for PEG-based hyperbranched polymers (HBPs) intended as tailored drug delivery vehicles.
Nirmal Marasini +8 more
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Lymphatic Biodistribution of Polylactide Nanoparticles [PDF]
Molecular Imaging, 2010 Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation. In this study, we report the formulation of Cy5-labeled polylactide (Cy5-PLA) nanoparticles with controlled size and surface features and the subsequent ...
Eric J. Chaney +4 more
openaire +3 more sources
Multiphysics pharmacokinetic model for targeted nanoparticles
Frontiers in Medical Technology, 2022 Nanoparticles (NP) are being increasingly explored as vehicles for targeted drug delivery because they can overcome free therapeutic limitations by drug encapsulation, thereby increasing solubility and transport across cell membranes.
Emma M. Glass +7 more
doaj +1 more source
Frontiers in Chemistry, 2022 Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system and chemical ...
Zheng Li +5 more
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Exosomes: Biological Pharmaceutical Nanovectors for Theranostics
Frontiers in Bioengineering and Biotechnology, 2022 Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression
Shindu C. Thomas +4 more
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Noninvasive Optical Imaging of Nanomedicine Biodistribution [PDF]
ACS Nano, 2012 Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of i.v. administered (chemo-) therapeutic agents. In recent years, ever more efforts in the nanomedicine field have employed optical imaging (OI) techniques to monitor biodistribution and target site accumulation.
Sijumon Kunjachan +10 more
openaire +3 more sources