Results 21 to 30 of about 125,907 (238)
Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]
, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar +8 more
core +2 more sources
Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]
, 2020 Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy +11 more
core +2 more sources
Nanomaterials, 2020 A better understanding of the impact of molecular size and linkers is important for PEG-based hyperbranched polymers (HBPs) intended as tailored drug delivery vehicles.
Nirmal Marasini +8 more
doaj +1 more source
Lymphatic Biodistribution of Polylactide Nanoparticles [PDF]
Molecular Imaging, 2010 Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation. In this study, we report the formulation of Cy5-labeled polylactide (Cy5-PLA) nanoparticles with controlled size and surface features and the subsequent ...
Eric J. Chaney +4 more
openaire +3 more sources
Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements [PDF]
, 2009 IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET.
Alley +33 more
core +3 more sources
Multiphysics pharmacokinetic model for targeted nanoparticles
Frontiers in Medical Technology, 2022 Nanoparticles (NP) are being increasingly explored as vehicles for targeted drug delivery because they can overcome free therapeutic limitations by drug encapsulation, thereby increasing solubility and transport across cell membranes.
Emma M. Glass +7 more
doaj +1 more source
Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. [PDF]
, 2018 Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in
Carroll, Valerie N +10 more
core +1 more source
Frontiers in Chemistry, 2022 Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system and chemical ...
Zheng Li +5 more
doaj +1 more source
Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. [PDF]
, 2018 The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue ...
Adams, Julia +13 more
core +2 more sources
Exosomes: Biological Pharmaceutical Nanovectors for Theranostics
Frontiers in Bioengineering and Biotechnology, 2022 Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression
Shindu C. Thomas +4 more
doaj +1 more source