Results 31 to 40 of about 125,907 (238)

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [PDF]

, 2007
Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR ...
Bartlett, Derek W., Davis, Mark E., Hildebrandt, Isabel J., Su, Helen, Weber, Wolfgang A.   +4 more
core   +2 more sources

Noninvasive Optical Imaging of Nanomedicine Biodistribution [PDF]

ACS Nano, 2012
Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of i.v. administered (chemo-) therapeutic agents. In recent years, ever more efforts in the nanomedicine field have employed optical imaging (OI) techniques to monitor biodistribution and target site accumulation.
Sijumon Kunjachan, Felix Gremse, Benjamin Theek, Patrick Koczera, Robert Pola, Michal Pechar, Tomas Etrych, Karel Ulbrich, Gert Storm, Fabian Kiessling, Twan Lammers   +10 more
openaire   +3 more sources

A Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction]

Drug Design, Development and Therapy, 2022
Chen J, Jiang H, Wu Y, Li Y, Gao Y. Drug Des Devel Ther. 2015;9:2265–2275. The Editor and Publisher of Drug Design, Development and Therapy wish to retract the published article.
Chen J, Jiang H, Wu Y, Li Y, Gao Y
doaj  

Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]

, 2016
With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S., Carideo, Luciano, Galli, Filippo, Lauri, Chiara, Pacilio, Massimiliano, Signore, Alberto, Valabrega, Stefano   +6 more
core   +2 more sources

Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. [PDF]

, 2016
OBJECTIVE: The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells.
Chen, Chang-Po, Kumar, Pardeep, Mehta, Neil, Paudyal, Bishnuhari, Thakur, Mathew L., Tripathi, Sushil Kumar, Wickstrom, Eric   +6 more
core   +2 more sources

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies [PDF]

, 2013
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trahtenherts, A Walker, Adam Walker, AM Wu, Armin Sepp, B Saunier, C. Andrew Boswell, CL Van Broekhoven, Clare Mudd, DJ Peng, DY Yang, E Dieperink, Edward Coulstock, ES Ward, F Pacifico, G Dusheiko, Gráinne Dunlevy, Jane Sosabowski, Jerome Burnet, JH Park, Julie Foster, KA Deal, Laura Goodall, LC Platanias, LJ Holt, LJ Holt, M Abe, M Loignon, M Spiess, Marie Davies, Milan Ovečka, MW Fried, MW Fried, P Kallinteri, R Duncan, R Gay, R Iorio, Rob Prince, T Eto, U Iyer, U Treichel, WM Pardridge, XQ Zhang, Y Zhang, YI Jeong, YY Seow   +45 more
core   +7 more sources

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
doaj   +1 more source

Radiation therapy combined with intracerebral administration of carboplatin for the treatment of brain tumors [PDF]

, 2014
Background: In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported by us with a 15 Gy dose (5 Gy ...
Agius, Lawrence, Barth, Rolf F., Grecula, John C., Gupta, Nilendu, Huo, Tianyao, Nakkula, Robin J., Weldon, Michael, Yang, Weilian   +7 more
core   +2 more sources

Biodistribution of P-selectin targeted microbubbles [PDF]

Journal of Drug Targeting, 2014
To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model.Antibodies were radiolabeled with Tc-99 m using the HYNIC method. Tc-99 m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and ...
Jason M, Warram, Anna G, Sorace, Marshall, Mahoney, Sharon, Samuel, Bryant, Harbin, Madhura, Joshi, Amber, Martin, Lee, Whitworth, Kenneth, Hoyt, Kurt R, Zinn   +9 more
openaire   +2 more sources

Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice

Nanomaterials
Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the possibilities, promising significant advancements in healthcare.
Qingyu Zhou, John C. Harding, Ping Fan, Ivan Spasojevic, Attila Kovacs, Antonina Akk, Adam Mitchell, Luke E. Springer, Joseph P. Gaut, Daniel A. Rauch, Samuel A. Wickline, Christine T. N. Pham, Katherine Fuh, Hua Pan   +13 more
doaj   +1 more source