Results 11 to 20 of about 541,804 (167)
Better bioinformatics through usability analysis [PDF]
Bioinformatics, 2008 Abstract Motivation: Improving the usability of bioinformatics resources enables researchers to find, interact with, share, compare and manipulate important information more effectively and efficiently. It thus enables researchers to gain improved insights into biological processes with the potential, ultimately, of yielding new ...
Bolchini, Davide +3 more
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Bioinformatics Analysis v1 [PDF]
, 2020 A plethora of biological processes like gene transcription, DNA replication, DNA recombination, and chromosome segregation are mediated through protein–DNA interactions. A powerful method for investigating proteins within a native chromatin environment in the cell is chromatin immunoprecipitation (ChIP).
Vasso Makrantoni +2 more
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RNA‐seq: Basic Bioinformatics Analysis [PDF]
Current Protocols in Molecular Biology, 2018 AbstractQuantitative analysis of gene expression is crucial for understanding the molecular mechanisms underlying genome regulation. RNA‐seq is a powerful platform for comprehensive investigation of the transcriptome. In this unit, we present a general bioinformatics workflow for the quantitative analysis of RNA‐seq data and describe a few current ...
Fei, Ji, Ruslan I, Sadreyev
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Bioinformatic analysis of the nucleolus [PDF]
Biochemical Journal, 2003 The nucleolus is a plurifunctional, nuclear organelle, which is responsible for ribosome biogenesis and many other functions in eukaryotes, including RNA processing, viral replication and tumour suppression. Our knowledge of the human nucleolar proteome has been expanded dramatically by the two recent MS studies on isolated nucleoli from HeLa cells ...
Leung, Anthony K.L. +3 more
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BMC Genomics, 2017 Background High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease ...
Vladimir A. Kuznetsov +2 more
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Plant Methods, 2022 Background Copy number determination is one of the first steps in the characterization of transgenic plant lines. The classical approach to this, Southern blotting, is time-consuming, expensive and requires massive amounts of high-quality genomic DNA ...
Jonas De Saeger +6 more
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Bioinformatics Databases: State of the Art and Research Perspectives [PDF]
, 2003 Bioinformatics or computational biology, i.e. the application of mathematical and computer science methods to solving problems in molecular biology that require large scale data, computation, and analysis, is a research area currently receiving a ...
Bry, François, Kröger, Peer
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Pathogens, 2020 To identify genome-based features characteristic of the avian and human pathogen Chlamydia (C.) psittaci and related chlamydiae, we analyzed whole-genome sequences of 33 strains belonging to 12 species. Using a novel genome analysis tool termed Roary ILP
Martin Hölzer +9 more
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AnaBench: a Web/CORBA-based workbench for biomolecular sequence analysis [PDF]
, 2003 Affiliation: Département de biochimie, Faculté de médecine, Université de MontréalBACKGROUND:Sequence data analyses such as gene identification, structure modeling or phylogenetic tree inference involve a variety of bioinformatics software tools.
Badidi, Elarbi +3 more
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Overview of Random Forest Methodology and Practical Guidance with Emphasis on Computational Biology and Bioinformatics [PDF]
, 2012 The Random Forest (RF) algorithm by Leo Breiman has become a standard data analysis tool in bioinformatics. It has shown excellent performance in settings where the number of variables is much larger than the number of observations, can cope with ...
Boulesteix, Anne-Laure +3 more
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