Results 81 to 90 of about 541,804 (167)
Unraveling mitotic protein networks by 3D multiplexed epitope drug screening
Molecular Systems Biology, 2018 Three‐dimensional protein localization intricately determines the functional coordination of cellular processes. The complex spatial context of protein landscape has been assessed by multiplexed immunofluorescent staining or mass spectrometry, applied to
Lorenz J Maier +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Propositionalisation of multiple sequence alignments using probabilistic models [PDF]
, 2008 Multiple sequence alignments play a central role in Bioinformatics. Most alignment representations are designed to facilitate knowledge extraction by human experts.
Holmes, Geoffrey +2 more
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Stem Cells International, 2016 Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue ...
Holger A. Russ +8 more
doaj +1 more source
Frontiers in Human Neuroscience, 2017 Sleep spindles are brief bursts of brain activity in the sigma frequency range (11–16 Hz) measured by electroencephalography (EEG) mostly during non-rapid eye movement (NREM) stage 2 sleep.
Min-Yin Liu +3 more
doaj +1 more source
Evaluating the Relationship Between Running Times and DNA Sequence Sizes using a Generic-Based Filtering Program. [PDF]
, 2008 Generic programming depends on the decomposition of programs into simpler components which may be developed separately and combined arbitrarily, subject only to well- defined interfaces.
Oluwagbemi, O. O., Omonhinmin, Conrad A.
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Bioinformatics Analysis of Estrogen-Responsive Genes [PDF]
, 2016 Estrogen is a steroid hormone that plays critical roles in a myriad of intracellular pathways. The expression of many genes is regulated through the steroid hormone receptors ESR1 and ESR2. These bind to DNA and modulate the expression of target genes.
openaire +3 more sources
Bioinformatic analysis of allergens [PDF]
Clinical and Translational Allergy, 2011 The number of resources containing data on the sequence, structure, and evolution of allergenic proteins has increased significantly in the last several years. At the same time, informatics resources related to the functioning of the immune system continue to mature rapidly.
openaire +2 more sources