Results 111 to 120 of about 16,187,582 (338)

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P., Barrett, Michael P., Gilbert, Ian H., Norval, Suzanne, Read, Kevin D., Ruda, Gian Filippo, Wong, Pui Ee   +6 more
core   +3 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Recent developments in the synthesis and biological activity of acridine/acridone analogues

, 2017
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs.
Monika Gensicka-Kowalewska, G. Cholewiński, K. Dzierzbicka   +2 more
semanticscholar   +1 more source

Research progress on functionof natural pigment astaxanthin

Liang you shipin ke-ji, 2019
Astaxanthin belongs to lutein in carotenoids and is a secondary metabolite synthesized by many microalgae, yeasts and bacteria. Astaxanthin has been listed as one of the best preventive and therapeutic agent for many acute or chronic diseases due to its ...
MENG Ang, ZHAO Xiao-yan, ZHU Yun-ping, ZHANG Xiao-wei, LIU Hong-kai, ZHU Hai-tao   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Investigation of temperature dependence of development and aging [PDF]

, 1969
Temperature dependence of maturation and metabolic rates in insects, and the failure of vital processes during development were investigated. The paper presented advances the general hypothesis that aging in biological systems is a consequence of the ...
Sacher, G. A.
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors

Molecules, 2019
Ugi four component reaction (Ugi-4CR) isocyanide-based multicomponent reactions were used to synthesize diN-substituted glycyl-phenylalanine (diNsGF) derivatives.
Luis Prent-Peñaloza, Alexander F. de la Torre, José L. Velázquez-Libera, Margarita Gutiérrez, Julio Caballero   +4 more
doaj   +1 more source

Repeated stressors in adulthood increase the rate of biological ageing [PDF]

, 2015
Background Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences.
Adelman, James S., Costantini, David, Greives, Timothy J., Hau, Michaela, Haussmann, Mark F., Matlack, Christa, Miranda, Ana Catarina, Partecke, Jesko, Quetting, Michael   +8 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source