Results 51 to 60 of about 7,692,235 (287)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Epigenetic Age Acceleration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Roetker et al Epigenetic age seems like a concept pulled from a futuristic science-fiction movie where a drop of blood is fed into a machine, in which an algorithm churns through an accumulation of chemical groups coating a strand of DNA and spits out an individual’s true age reflecting a lifetime of experiences and exposures ...
openaire   +2 more sources

Acceleration of cardiovascular-biological age by amphetamine exposure is a power function of chronological age [PDF]

Heart Asia, 2017
Background Amphetamine abuse is becoming more widespread internationally. The possibility that its many cardiovascular complications are associated with a prematurely aged cardiovascular system, and indeed biological organism systemically, has not been addressed ...
Albert Stuart Reece, Amanda Norman, Gary Kenneth Hulse   +2 more
openaire   +2 more sources

Vertical evolution of auroral acceleration at substorm onset [PDF]

, 2009
This study describes the onset process of auroral substorms in connection with the vertical evolution of auroral particle acceleration, on the basis of auroral kilometric radiation (AKR) dynamics.
Morioka, A., A. Morioka, R. R. Anderson, Misawa, H., Anderson, R.R., J. D. Menietti, Honary, F., F. Tsuchiya, Tsuchiya, F., Miyoshi, Y., Parks, G.K., Menietti, J.D., H. Misawa, G. K. Parks, Y. Miyoshi, Yumoto, K., F. Honary, K. Yumoto   +17 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Accelerating aging research: How can we measure the rate of biologic aging? [PDF]

Experimental Gerontology, 2015
Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such ...
Joseph B, Margolick, Luigi, Ferrucci
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Living in poverty and accelerated biological aging: evidence from population-representative sample of U.S. adults

BMC Public Health
Background Biological aging reflects a decline in the functions and integrity of the human body that is closely related to chronological aging. A variety of biomarkers have been found to predict biological age.
Andrea Dalecka, Anna Bartoskova Polcrova, Hynek Pikhart, Martin Bobak, Albert J. Ksinan   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank

Frontiers in Endocrinology
Background and aimsMetabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder linked to increased all-cause and cardiovascular mortality.
Xue Yang, Xue Yang, Sicheng Li, Qingping Xue, Peijing Yan, Qian Li, Yi Gong, Xiayue Fan, Wenzhi Zhu, Shiyi Wu, Shanshan Zhang, Ko Willems van Dijk, Ko Willems van Dijk, Patrick C.N. Rensen, Patrick C.N. Rensen, Ruifang Li-Gao, Yanan Wang, Yanan Wang, Ting Yao   +18 more
doaj   +1 more source