Results 151 to 160 of about 10,327,060 (336)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enzymatic Activity and Nutrient Profile Assessment of Three Pleurotus Species Under Pasteurized Cenchrus fungigraminus Cultivation

Current Issues in Molecular Biology
Oyster mushrooms are regarded as one of the most significant edible mushrooms in terms of commercial value because of their rich nutritional profile.
Nsanzinshuti Aimable, Hatungimana Mediatrice, Irambona Claude, Jules Biregeya, Yingping Hu, Hengyu Zhou, Penghu Liu, Jing Li, Zhanxi Lin, Guodong Lu, Dongmei Lin   +10 more
doaj   +1 more source

TRADABLE RISK PERMITS TO PREVENT FUTURE INTRODUCTIONS OF ALIEN INVASIVE SPECIES INTO THE GREAT LAKES [PDF]

Alien invasive species contribute to biodiversity loss and cause billions of dollars of economic damage in the Great Lakes. We examine the design and efficiency of a tradeable permit system for biological pollution due to alien species that invade the ...
Horan, Richard D., Lupi, Frank
core   +1 more source

Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in an animal model of multiple sclerosis. [PDF]

Biomater Sci, 2020
Song Z, Khaw YM, Pacheco LA, Tseng KY, Tan Z, Cai K, Ponnusamy E, Cheng J, Inoue M.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats. [PDF]

Asian Pac J Cancer Prev, 2020
Aboulthana WM, Ibrahim NE, Osman NM, Seif MM, Hassan AK, Youssef AM, El-Feky AM, Madboli AA.   +7 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Biological assessment of fungicides in vitro

Зерновое хозяйство России, 2018
During the testing of plant protection methods on the fields we need a longer period of time, large expenditure of material and labor. It’s not always possible to evaluate the efficiency of chemical drugs to one definite type of pathogen.
V. V. Chekmarev, N. N. Dubrovskaya, O. I. Korabelskaya, G. N. Buchneva   +3 more
doaj   +2 more sources

Evaluation of the Influence of Varied Juncao Grass Substrates on Physiological and Enzymatic Reactions of Pleurotus ostreatus

Current Issues in Molecular Biology
Pleurotus ostreutus is one of the world’s most commonly consumed mushrooms. The cultivation of mushrooms using wood resources usually results in environmental issues such as deforestation.
Irambona Claude, Nsanzinshuti Aimable, Hatungimana Mediatrice, Hengyu Zhou, Dongmei Lin, Penghu Liu, Zhanxi Lin   +6 more
doaj   +1 more source