Results 51 to 60 of about 743,637 (245)
Educating Future Nursing Scientists: Recommendations for Integrating Omics Content in PhD Programs [PDF]
, 2015 Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and ...
Cindy M. Anderson +13 more
core +3 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Multiplexed protein profiling reveals spatial subcellular signaling networks
iScience, 2022 Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays ...
Shuangyi Cai +7 more
doaj
Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification [PDF]
, 2016 Motivation: Prediction of phenotypes from high-dimensional data is a crucial task in precision biology and medicine. Many technologies employ genomic biomarkers to characterize phenotypes.
Acunzo, Mario +5 more
core +3 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
A light-switching pyrene probe to detect phase-separated biomolecules
iScience, 2021 Summary: Biomolecules may undergo liquid–liquid phase separation (LLPS) to spatiotemporally compartmentalize and regulate diverse biological processes. Because the number of tools to directly probe LLPS is limited (ie. FRAP, FRET, fluorescence microscopy,
Masaharu Hazawa +9 more
doaj
A Survey on Latent Tree Models and Applications [PDF]
Journal Of Artificial Intelligence Research, Volume 47, pages
157-203, 2013, 2014 In data analysis, latent variables play a central role because they help provide powerful insights into a wide variety of phenomena, ranging from biological to human sciences. The latent tree model, a particular type of probabilistic graphical models, deserves attention.
arxiv +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Precision vibratome for high-speed ultrathin biotissue cutting and organ-wide imaging
iScience, 2021 Summary: Cutting tissues into ultrathin slices is highly desired in sectioning-based organ-wide imaging. However, it is difficult to perform tissue cutting at a high speed with excellent quality.
Yafeng Li +8 more
doaj
Data Science in Biomedicine [PDF]
arXiv, 2019 We highlight the role of Data Science in Biomedicine. Our manuscript goes from the general to the particular, presenting a global definition of Data Science and showing the trend for this discipline together with the terms of cloud computing and big data.
arxiv