Results 91 to 100 of about 3,349,315 (392)

UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis [PDF]

, 2018
Background: Rheumatoid arthritis (RA) causes painful joint inflammation and is incurable, but treatments control RA. Drug regimens are complex, and patients often do not take their medication as expected.
Kumar, K, Mallen, C, Raizada, S, Stack, R   +3 more
core   +4 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study

EClinicalMedicine, 2021
Background: IBI362 (LY3305677) is a novel weekly-dose glucagon-like peptide-1 and glucagon receptor dual agonist being developed for the treatment of obesity and type 2 diabetes.
Linong Ji, Hongwei Jiang, Pei An, Huan Deng, Meng Liu, Li Li, Liqi Feng, Baili Song, Han Han-Zhang, Qingyang Ma, Lei Qian   +10 more
doaj  

A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development

mAbs, 2020
Glycosylation is a common post-translational modification and critical quality attribute that can modulate the efficacy of therapeutic proteins.
Zaneer Segu, Todd Stone, Claudia Berdugo, Anthony Roberts, Emma Doud, Yunsong Li   +5 more
doaj   +1 more source

The Effect of Biologic Materials and Oral Steroids on Radiographic and Clinical Outcomes of Horizontal Alveolar Ridge Augmentation. [PDF]

, 2018
The purpose of this study was to investigate if the addition of biologic materials and/or oral steroids would affect horizontal bone gain, or the bone density of the grafted bone in horizontal alveolar ridge augmentations.
Reichert, Amy
core   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources

Biologics in the treatment of pustular psoriasis

Expert Opinion on Drug Safety, 2020
Introduction Pustular psoriasis is a group of skin diseases characterized by neutrophil infiltration in the epidermis and formation of sterile pustules.
Wen-Ming Wang, H. Jin
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Efficient Nonviral Transfection of Human Bone Marrow Mesenchymal Stromal Cells Shown Using Placental Growth Factor Overexpression

Stem Cells International, 2018
Background. Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic potential due to their immunomodulatory and tissue regenerative properties.
Winston Y. Cheung, Owen Hovey, Jonathan M. Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Jessie R. Lavoie   +6 more
doaj   +1 more source

Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas

Frontiers in Immunology, 2018
NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts.
Massimo Fantini, Justin M. David, Olga Saric, Alexander Dubeykovskiy, Yongzhi Cui, Sharon A. Mavroukakis, Andrew Bristol, Christina M. Annunziata, Kwong Y. Tsang, Philip M. Arlen   +9 more
doaj   +1 more source