Results 111 to 120 of about 5,448,839 (367)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

NEW SILK: Studying experimental touchpoints between material science, synthetic biology, design and art

Temes de Disseny, 2018
This article presents a study in which new materials are developed through experimental knowledge construction and knowledge exchange between different disciplines. The New Silk research project (2017-2020) is the building block for the research.
Kirsi Niinimäki, Camilla Groth, Pirjo Kääriäinen   +2 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes

iScience, 2021
Summary: The mouse eye is used to model central nervous system development, pathology, angiogenesis, tumorigenesis, and regenerative therapies. To facilitate the analysis of these processes, we developed an optimized tissue clearing and depigmentation ...
Akshay Gurdita, Philip E.B. Nickerson, Neno T. Pokrajac, Arturo Ortín-Martínez, En Leh Samuel Tsai, Lacrimioara Comanita, Nicole E. Yan, Parnian Dolati, Nobuhiko Tachibana, Zhongda C. Liu, Joel D. Pearson, Danian Chen, Rod Bremner, Valerie A. Wallace   +13 more
doaj  

DRAWING BASED MODELLING BERBANTUAN EBEAM CAPTURE UNTUK MENSTIMULASI REPRESENTASI MIKROSKOPIS CALON GURU BIOLOGI

Jurnal BIOEDUIN, 2019
This study aims to determine the drawing based modeling implementation aid eBeam Capture in stimulating the Microscopic Representation of Prospective Biology Teachers in the Digital Era.
Tomi Hidayat, Adi Rahmat, Sri Redjeki, Taufik Rahman   +3 more
doaj   +1 more source

Additional file 2 of Dysregulation of ribosome-related genes in ankylosing spondylitis: a systems biology approach and experimental method

, 2021
Additional file 2: Supplementary File 2.pdf.
Lari, Arezou, Pourbadie, Hamid Gholami, Sharifi-Zarchi, Ali, Akhtari, Maryam, Samimi, Leila Nejatbakhsh, Jamshidi, Ahmadreza, Mahmoudi, Mahdi   +6 more
openaire   +1 more source

Numerical investigation of Differential Biological Models via RBF collocation Method with Genetic Strategy [PDF]

, 2017
In this paper, we use Kansa method for solving the system of differential equations in the area of biology. One of the challenges in Kansa method is picking out an optimum value for Shape parameter in Radial Basis Function to achieve the best result of the method because there are not any available analytical approaches for obtaining optimum Shape ...
arxiv   +1 more source

Optimization in computational systems biology [PDF]

, 2008
Optimization aims to make a system or design as effective or functional as possible. Mathematical optimization methods are widely used in engineering, economics and science.
A Kremling, A Ma'ayan, A Meyer, A Varma, A Villalobos, AP Burgard, BS Adiwijaya, CA Floudas, CA Floudas, CG Moles, CS Henry, D Faller, D Lebiedz, D Segre, D Segrè, DB Kell, E Andrianantoandro, E Balsa-Canto, E Balsa-Canto, E Walter, ED Sontag, ET Papoutsakis, F Llaneras, FG Vital-Lopez, FJ Doyle, FP Casey, GB Dantzig, GY Jung, HJ Greenberg, I Famili, J Forster, J Handl, J Nielsen, J Stelling, J Tomshine, J Varner, JM Carlson, JR Banga, JS Edwards, Julio R Banga, JW Zwolak, K Jaqaman, KE Tyo, KG Gadkar, KG Gadkar, KH Cho, KH Cho, KJ Kauffman, KR Patil, L Kuepfer, L Ljung, M Dasika, M Heinemann, M Rodriguez-Fernandez, M Rodriguez-Fernandez, MA Nowak, MKS Yeung, MP Styczynski, MS Dasika, N Bagheri, ND Price, NV Torres, O Wolkenhauer, P Larranaga, P Mendes, R Goodacre, R Heinrich, R Heinrich, R Horst, R Horst, R Mahadevan, R Schuetz, R Tanaka, R Thomas, RM Alexander, RS Wang, RS Wang, S Han, S Kim, S Lee, S Reinker, SP Boyd, T Pfeiffer, TD Vo, TD Vo, U Alon, V Hatzimanikatis, V Hatzimanikatis, V Sotiropoulos, WJ Sutherland, XJ Feng, XX Lin, Y Cai, Y Wang, YJ Chang, YN Kaznessis   +95 more
core   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

THE ROLE OF WILD BIRDS IN PRESERVATION AND PREVALENCE OF AVIAN PARAMYXOVIRUS SEROTYPE 1 (NEWCASTLE DISEASE VIRUSES) IN SIBERIA AND THE FAR EAST, RUSSIA

Юг России: экология, развитие, 2016
The aim is to evaluate ecological diversity of wild birds in Siberia and the Russian Far East, which are carriers of Newcastle disease virus that belongs to potentially dangerous pathogen for poultry.Methods.
A. V. Glushchenko, K. S. Yurchenko, A. K. Yurlov, Yu. G. Yushkov, M. Yu. Shchelkanov, A. M. Shestopalov   +5 more
doaj   +1 more source