Results 51 to 60 of about 113,231 (318)

The small molecule ephrin receptor inhibitor, GLPG1790, Reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma models [PDF]

, 2019
Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
Beirinckx, Filip, Colapietro, Alessandro, Cristiano, Loredana, Delle Monache, Simona, Festuccia, Claudio, Gravina, Giovanni, Lorenzon, Giocondo, Mancini, Andrea, Marampon, Francesco, Martellucci, Stefano, Mattei, Vincenzo, Pujuguet, Philippe, Saniere, Laurent, Sferra, Roberta, van der Aar, Ellen, Vitale, Flora   +15 more
core   +2 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Combining motility and bioluminescent signalling aids mate finding in deep-sea fish: a simulation study [PDF]

, 2005
We present a model to estimate the mean time required for mate finding among deep-sea fish as a function of motility and the extent of bioluminescent signalling.
Bailey, David M., Ruxton, Graeme D.
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

ATP-Bioluminescence as a method to evaluated microbiological quality of UHT milk

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2014
New approaches are needed to quickly indicate possible contamination of UHT milk, among them the technique of ATP-Bioluminescence. Therefore, the aim of this study was to compare the results of culture methods with the results of ATP-Bioluminescence ...
A.F. Cunha, A.D. Lage, M.M. Pereira e Araújo, C.F. Abreu, A.R. Tassinari, M.A. Ferraz, K. Davenport, M.M.O.P. Cerqueira   +7 more
doaj   +1 more source

Shell Neurons of the Master Circadian Clock Coordinate the Phase of Tissue Clocks Throughout the Brain and Body [PDF]

, 2015
Background: Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination remains ill defined.
Baba, Kenkichi, Baker, Kimberly M., Bartness, Timothy J., Callif, Ben L., Castanon-Cervantes, Oscar, Davidson, Alec J., Ehlen, J. Christopher, Evans, Jennifer A., Kloehn, Ian, Leise, Tanya, Mitchell, Andrew S., Paul, Ketema N., Suen, Ting-Chung, Teubner, Brett J.W., Tosini, Gianluca   +14 more
core   +2 more sources

Transformative Bioactive Wear Resistant Ti3Au:N and Ti3Au:O Coatings for Medical Implants and Devices

Advanced Healthcare Materials, EarlyView.
Coatings of titanium‐gold are grown in nitrogen and oxygen environments via magnetron sputtering to simultaneously enhance their biotribological and antibacterial properties. The coatings are highly crystalline with superhard scratch‐resistant surfaces and wear rates 20 times lower than the bare Ti‐6Al‐4V substrate.
Cecil Cherian Lukose, Ioannis Anestopoulos, Iraklis‐Stavros Panagiotidis, Guillaume Zoppi, Anna M Black, Lynn G. Dover, Leon Bowen, Ángel Serrano‐Aroca, Lorenzo Mendola, Davide Morrone, Mihalis I. Panayiotidis, Martin Birkett   +11 more
wiley   +1 more source

Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence

Frontiers in Bioengineering and Biotechnology, 2019
Early detection of tumors is today a major challenge and requires sensitive imaging methodologies coupled with new efficient probes. In vivo optical bioluminescence imaging has been widely used in the field of preclinical oncology to visualize tumors and
Fabiane Sônego, Sophie Bouccara, Thomas Pons, Nicolas Lequeux, Anne Danckaert, Jean-Yves Tinevez, Israt S. Alam, Spencer L. Shorte, Régis Tournebize   +8 more
doaj   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae

Bio-Protocol, 2017
The proof of concept for bioluminescence monitoring of neural activity in zebrafish with the genetically encoded calcium indicator GFP-aequorin has been previously described (Naumann et al., 2010) but challenges remain.
Steven Knafo, Andrew Prendergast, Olivier Thouvenin, Sophie Figueiredo, Claire Wyart   +4 more
doaj   +1 more source