Results 41 to 50 of about 64,944 (323)

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]

, 2016
Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S, Daynac, Mathieu, Grossauer, Stefan, James, C David, Koeck, Katharina, McMahon, Martin, Meyers, Ian D, Murphy, Nicole E, Nicolaides, Theodore P, Petritsch, Claudia K, Phillips, Joanna J, Truffaux, Nathalene, Truong, Albert Y   +12 more
core   +1 more source

The in vitro and in vivo effects of constitutive light expression on a bioluminescent strain of the mouse enteropathogen Citrobacter rodentium [PDF]

PeerJ, 2016
Bioluminescent reporter genes, such as those from fireflies and bacteria, let researchers use light production as a non-invasive and non-destructive surrogate measure of microbial numbers in a wide variety of environments.
Hannah M. Read, Grant Mills, Sarah Johnson, Peter Tsai, James Dalton, Lars Barquist, Cristin G. Print, Wayne M. Patrick, Siouxsie Wiles   +8 more
doaj   +2 more sources

Red-Shifted Aequorin Variants Incorporating Non-Canonical Amino Acids: Applications in In Vivo Imaging. [PDF]

PLoS ONE, 2016
The increased importance of in vivo diagnostics has posed new demands for imaging technologies. In that regard, there is a need for imaging molecules capable of expanding the applications of current state-of-the-art imaging in vivo diagnostics.
Kristen M Grinstead, Laura Rowe, Charles M Ensor, Smita Joel, Pirouz Daftarian, Emre Dikici, Jean-Marc Zingg, Sylvia Daunert   +7 more
doaj   +1 more source

Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]

, 2012
The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS, Harmer, Stacey L, Jones, Matthew A, McNicol, Jim, Simpson, Craig G, Williams, Brian A   +5 more
core   +1 more source

Rapid Multicomponent Bioluminescence Imaging via Substrate Unmixing. [PDF]

ACS Chem Biol, 2021
ABSTRACTEngineered luciferases and luciferins have dramatically expanded the scope of bioluminescence imaging in recent years. Multicomponent tracking remains challenging, though, due to a lack of streamlined methods to visualize combinations of bioluminescent reporters.
Rathbun CM, Ionkina AA, Yao Z, Jones KA, Porterfield WB, Prescher JA.   +5 more
europepmc   +7 more sources

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources

U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform [PDF]

, 2014
Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes.
Beekman, Freek J, Buckle, Tessa, Bunschoten, Anton, Josephson, Lee, Kreuger, Rob, Mahn, Wendy A, van Leeuwen, Fijs WB, van Oosterom, Matthias N   +7 more
core   +1 more source

In Vivo Imaging of Immune Rejection of MIN6 Cells Transplanted in C3H Mice

Cells
Recently, we successfully utilized noninvasive magnetic resonance and bioluminescence imaging to track MIN6 cells subcutaneously transplanted in immunocompromised nude mice for up to 64 days.
Jyuhn-Huarng Juang, Chen-Ling Chen, Chen-Wei Kao, Shu-Ting Wu, Chia-Rui Shen   +4 more
doaj   +1 more source

Novel locally active estrogens accelerate cutaneous wound healing-part 2 [PDF]

, 2017
Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds.
Bartoli, Gabriele, Bella, Angela La, Brufani, Mario, Ceccacci, Francesca, Ciana, Paolo, D’Aiuto, Virginia, FILOCAMO, Luigi, LEONELLI, Francesca, Maggi, Adriana, MARINI BETTOLO, Rinaldo, Meda, Clara, MIGNECO, Luisa Maria, Rizzi, Nicoletta   +12 more
core   +2 more sources

Erratum: Cellular Bioluminescence Imaging [PDF]

Cold Spring Harbor Protocols, 2016
The publisher apologizes for several errors that were inadvertently introduced during the composition of earlier versions of this article. The following corrections have been made to the article and are included in the current PDF and HTML versions. • The last sentence of the fourth paragraph on p.
David K. Welsh, Takako Noguchi
openaire   +1 more source