Results 131 to 140 of about 12,382 (217)

Corrigendum: Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation

Frontiers in Bioengineering and Biotechnology, 2023
Catarina Almeida, Augusto Q. Pedro, Ana P. M. Tavares, Márcia C. Neves, Mara G. Freire   +4 more
doaj   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2629-2642, October 2026.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Translating Blue Light Stimulation From Batch to Perfusion: Process and Intracellular Metabolic Analysis

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2729-2746, October 2026.
ABSTRACT Improving cell‐specific productivity remains a central objective in biopharmaceutical manufacturing. In this study, the effect of blue light illumination on IgG1‐producing CHO DP‐12 cells was systematically evaluated across batch, fed‐batch, and perfusion cultivations in controlled 3 L bioreactor systems.
Stefanie Föller, Attila Teleki, Ralf Takors   +2 more
wiley   +1 more source

Strategic selection of microbial cell factories for sustainable and application-specific terpenoid production. [PDF]

Front Bioeng Biotechnol
Shukla V, Shukla V, Rawat S, Singh V, Phulara SC.   +4 more
europepmc   +1 more source

Revisiting the Carbon Footprint of Single‐Use Technologies in Biomanufacturing: A Bottom‐Up Analysis Reveals a Paradigm Shift

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2802-2814, October 2026.
ABSTRACT The biopharmaceutical industry increasingly relies on single‐use technologies (SUT) for operational flexibility. For a long time, SUT was considered more sustainable than stainless‐steel (SST) systems due to water and energy savings. This study re‐evaluates this paradigm via a detailed bottom‐up analysis of the SUT carbon footprint at the 2000 
Jan Reiners, Katharina Bruno‐Thakur, Daina Romeo, Weronika Kuśmierczyk, Ferdinand Stückler   +4 more
wiley   +1 more source

Describing the persistence landscape for introducing microbes into complex communities. [PDF]

Appl Environ Microbiol
McDermott JE, Nelson WC, Zimmerman AE, Anthony W, Coleman-Derr D, Elmore JR, Nitka T, McClure RS, Handakumbura PP, Guss AM, Wheeler TJ, Egbert RG.   +11 more
europepmc   +1 more source

Perfusion Cell Cultures: Is the Technology Worthwhile for Biopharmaceutical Production?

ChemBioEng Reviews, Volume 13, Issue 5, October 2026.
The biotechnology industry is pursuing innovation and robust production, yet many biopharmaceuticals are manufactured from batch or fed‐batch cell cultures. Perfusion processes, offering higher yields and efficiency, remain underused despite their maturity.
Francesco Iannacci, Mattia Sponchioni
wiley   +1 more source

Toward a 4D genome annotation of CHO cells for biomanufacturing. [PDF]

Trends Biotechnol
Di Giusto P, Tat J, Lewis NE.
europepmc   +1 more source

Integrated Multi‐Omics and Single‐Cell Analyses Implicate NOX4 as an Icariin‐Associated Oxidative Stress Regulatory Node in Gastric Cancer

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
NOX4 represents a candidate icariin‐associated regulatory node in gastric cancer and may contribute to the cellular response to icariin through redox‐related signaling. ABSTRACT Icariin, a prenylated flavonoid glycoside from Epimedium species, is a representative dietary polyphenol with antioxidant, anti‐inflammatory, and antitumor properties.
Na Liang, Junyan Li, Zuchao Luo, Zijuan Song, Liyuan Zhang, Chengyi Zou, Chunming Li, Bochen Pan, Jiawei Yang   +8 more
wiley   +1 more source

Editorial: Advancements in microbial engineering for natural product synthesis. [PDF]

Front Bioeng Biotechnol
Li C, Li K, Huang Y.
europepmc   +1 more source