Results 51 to 60 of about 12,382 (217)

PCN‐700: A Model Platform for Crystallographic Probing of Coordination Behavior in Metal–Organic Frameworks

Angewandte Chemie, EarlyView.
Linker installation in PCN‐700 provides a unique platform for precisely modulating coordination environments within a crystalline framework. By enabling controlled incorporation of diverse linkers while maintaining structural integrity, PCN‐700 offers new opportunities to unravel the fundamental principles governing coordination chemistry, including ...
Zongsu Han, Jiatong Huo, Hong‐Cai Zhou
wiley   +2 more sources

DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese Hamster Ovary Cells

Pharmaceutics, 2021
Methotrexate (MTX)-mediated gene amplification has been widely used in Chinese hamster ovary (CHO) cells for the biomanufacturing of therapeutic proteins.
Jong Youn Baik, Hye-Jin Han, Kelvin H. Lee   +2 more
doaj   +1 more source

Biomanufacturing is Booming!

, 2022
This video from InnovATEBIO provides three presentations about biomanufacturing. In the first presentation, Jan Chalupny talks about kits for teaching biomanufacturing concepts in high school. Chalupny describes the kits, their contents, and how
Nash, Bruce, 1968-, Hewlett, James A., Chalupny, Jan   +2 more
core   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration

Bioengineering, 2023
Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical scale remain limited.
Kiera D. Dwyer, Rajeev J. Kant, Arvin H. Soepriatna, Stephanie M. Roser, Mark C. Daley, Sharif A. Sabe, Cynthia M. Xu, Bum-Rak Choi, Frank W. Sellke, Kareen L. K. Coulombe   +9 more
doaj   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Physiological and biochemical variations in different pepper (Capsicum annuum var. conoides) varieties under salt stress

BMC Plant Biology
Background Pepper (Capsicum annuum L.), an annual herbaceous plant of the Solanaceae family, is extensively cultivated as both a fresh vegetable and a condiment, ranking among the most widely grown vegetable crops globally.
Xinru Li, Yamin Zhang, Doudou Zhang, Junhao Liu, Nan Xu, Yike Zhong, Xu Han, Zhuona Chen, Yingpeng Hua, Nan Lu, Bo Li, Yinggang Wang, Wenyue Li, Haihong Shang   +13 more
doaj   +1 more source

Leveraging Walnut Somatic Embryos as a Biomanufacturing Platform for Recombinant Proteins and Metabolites

BioTech
Biomanufacturing enables novel sources of compounds with constant demand, such as food coloring and preservatives, as well as new compounds with peak demand, such as diagnostics and vaccines. The COVID-19 pandemic has highlighted the need for alternative
Paulo A. Zaini, Katherine R. Haddad, Noah G. Feinberg, Yakir Ophir, Somen Nandi, Karen A. McDonald, Abhaya M. Dandekar   +6 more
doaj   +1 more source

Assessing the suitability of cell counting methods during different stages of a cell processing workflow using an ISO 20391-2 guided study design and analysis

Frontiers in Bioengineering and Biotechnology, 2023
Cell counting is a fundamental measurement for determining viable cell numbers in biomanufacturing processes. The properties of different cell types and the range of intended uses for cell counts within a biomanufacturing process can lead to challenges ...
Colleen Richards, Sumona Sarkar, Jennifer Kandell, Richard Snyder, Uma Lakshmipathy   +4 more
doaj   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source