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Introduction to Biomanufacturing
The Northeast Biomanufacturing Center and Collaborative (NBC2) has created this webpage that provides an introduction and overview to the field of biomanufacturing. Links to a three-part series of articles on the topic are included. In
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter +10 more
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Biotechnology and Bioengineering, EarlyView.With a thermotolerant C. necator mutant the SCP production costs can be decreased by $0.98/kg. ABSTRACT Autotrophic CO2 conversion to Single Cell Protein (SCP) using H2 and O2 is gaining commercial traction for food and feed production. Cupriavidus necator H16 is a key chassis organism for this “knallgas” fermentation, but industrial operation is ...
Lars Puiman +2 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Accurate prediction of bioprocess scale‐up is critical for accelerating the deployment of novel and sustainable biomanufacturing systems. However, this remains challenging as multi‐scale data is expensive to generate and mechanistic understanding is often incomplete, leading upscaling decisions to rely heavily on empirical expertise. This work
Harvey Al‐Ramadhan +3 more
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, 2009 Teachers' Domain presents this video as part of a series on advanced technological education. The clip features a biomanufacturing supervisor for a medical device company.
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Biomanufacturing Laboratory Manual
The Northeast Biomanufacturing Center and Collaborative (NBC2) has created this laboratory manual that can be downloaded as a pdf. The Biomanufacturing Laboratory Manual is 390 pages in length. It is divided into ten
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, and macroscopic scales to predict how inputs shape bioprocess ...
Yuming Zeng +3 more
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Mechanistic Digital Model for Real‐Time Monitoring and Optimization of Adenovirus Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adenoviral vectors are a critical vaccine platform, with billions of vaccine doses administered during the COVID‐19 pandemic. In addition, they are promising therapeutics for cancer treatment. To advance their manufacturing, real‐time monitoring of adenovirus production is essential for process optimization, yield improvement, and product ...
Xingge Xu +4 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT The glutamine synthetase expression system is widely used for therapeutic protein biomanufacturing in Chinese hamster ovary (CHO) cells. Here, we present the design of an enhanced glutamine synthetase vector for generating CHOK1SV GS‐KO stable pools that produce recombinant proteins at multigram‐per‐liter levels. We first developed a synthetic
Yusuf B. Johari +11 more
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Introduction to Biomanufacturing Textbook
The Northeast Biomanufacturing Center and Collaborative (NBC2) has created this introductory textbook on Biomanufacturing that features fifteen industry subject matter expert-authored units.
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