Results 1 to 10 of about 1,948,876 (297)

A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis

Scientific Reports, 2023
Over the past decade, automation of digital image analysis has become commonplace in both research and clinical settings. Spurred by recent advances in artificial intelligence and machine learning (AI/ML), tissue sub-compartments and cellular phenotypes ...
Edward D. Bonnevie, Eric Dobrzynski, Dylan Steiner, Deon Hildebrand, James Monslow, Mohan Singh, Vilma Decman, David L. Krull   +7 more
doaj   +1 more source

Citrullinated and MMP-degraded vimentin is associated with chronic pulmonary diseases and genetic variants in PADI3/PADI4 and CFH in postmenopausal women

Scientific Reports, 2023
Citrullinated vimentin has been linked to several chronic and autoimmune diseases, but how citrullinated vimentin is associated with disease prevalence and genetic variants in a clinical setting remains unknown.
Cecilie Liv Bager, Joseph P. M. Blair, Man-Hung Eric Tang, Joachim Høg Mortensen, Anne-Christine Bay-Jensen, Peder Frederiksen, Diana Leeming, Claus Christiansen, Morten Asser Karsdal   +8 more
doaj   +1 more source

Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy

Journal of Experimental & Clinical Cancer Research, 2021
Despite the overall clinical success of immune checkpoint inhibitors (ICIs) for treating patients with solid tumors, a large number of patients do not benefit from this approach. Consequently, there is a need for predictive biomarkers. The most prevalent
Christina Jensen, Neel I. Nissen, Claus S. Von Arenstorff, Morten A. Karsdal, Nicholas Willumsen   +4 more
doaj   +1 more source

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Briefings Bioinform., 2021
Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response.
D. Maeser, Robert F. Gruener, R. Huang
semanticscholar   +1 more source

Intermittent Dynamic Compression Confers Anabolic Effects in Articular Cartilage

Applied Sciences, 2021
(1) Background: Mechanical loading is an essential part of the function and maintenance of the joint. Despite the importance of intermittent mechanical loading, this factor is rarely considered in preclinical models of cartilage, limiting their ...
Amalie Engstrøm, Frederik S. Gillesberg, Solveig S. Groen, Peder Frederiksen, Anne-Christine Bay-Jensen, Morten A. Karsdal, Christian S. Thudium   +6 more
doaj   +1 more source

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension,
Shi Qiu, Ying Cai, Hong Yao, Chunsheng Lin, Yiqiang Xie, Songqi Tang, Aihua Zhang   +6 more
semanticscholar   +1 more source

Lot-to-Lot Variance in Immunoassays—Causes, Consequences, and Solutions

Diagnostics, 2023
Immunoassays, which have gained popularity in clinical practice and modern biomedical research, play an increasingly important role in quantifying various analytes in biological samples.
Yunyun Luo, Martin Pehrsson, Lasse Langholm, Morten Karsdal, Anne-Christine Bay-Jensen, Shu Sun   +5 more
doaj   +1 more source

Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision medicine

bioRxiv, 2023
Personalized interventions are deemed vital given the intricate characteristics, advancement, inherent genetic composition, and diversity of cardiovascular diseases (CVDs). The appropriate utilization of artificial intelligence (AI) and machine learning (
William DeGroat, Habiba Abdelhalim, Kush Patel, Dinesh Mendhe, Saman Zeeshan, Zeeshan Ahmed   +5 more
semanticscholar   +1 more source

The activation fragment of PAR2 is elevated in serum from patients with rheumatoid arthritis and reduced in response to anti-IL6R treatment

Scientific Reports, 2021
Osteoarthritis (OA) and rheumatoid arthritis (RA) are serious and painful diseases. Protease-activated receptor 2 (PAR2) is involved in the pathology of both OA and RA including roles in synovial hyperplasia, cartilage destruction, osteophyogenesis and ...
Stefania Kalogera, Yi He, Anne-Christine Bay-Jensen, Thorbjørn Gantzel, Shu Sun, Tina Manon-Jensen, Morten Asser Karsdal, Christian S. Thudium   +7 more
doaj   +1 more source

Biomarkers of aging for the identification and evaluation of longevity interventions.

Cell, 2023
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field.
M. Moqri, Chiara M S Herzog, J. Poganik, J. Justice, Daniel W Belsky, A. Higgins-Chen, A. Moskalev, Georg Fuellen, A. Cohen, I. Bautmans, M. Widschwendter, Jingzhong Ding, Alexander Fleming, J. Mannick, J. Han, A. A. Zhavoronkov, N. Barzilai, M. Kaeberlein, Steven Cummings, B. Kennedy, L. Ferrucci, Steve Horvath, E. Verdin, A. Maier, Michael P. Snyder, V. Sebastiano, V. Gladyshev   +26 more
semanticscholar   +1 more source