Results 1 to 10 of about 2,395,258 (429)
Conditional Screening for Ultra-high Dimensional Covariates with Survival Outcomes [PDF]
arXiv, 2016 Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine. The emergence of large-scale biomedical survival studies, which typically involve excessive number of biomarkers, has brought high ...
Hong, Hyokyoung Grace +2 more
arxiv +5 more sources
Scientific Reports, 2023 Over the past decade, automation of digital image analysis has become commonplace in both research and clinical settings. Spurred by recent advances in artificial intelligence and machine learning (AI/ML), tissue sub-compartments and cellular phenotypes ...
Edward D. Bonnevie +7 more
doaj +1 more source
Scientific Reports, 2023 Citrullinated vimentin has been linked to several chronic and autoimmune diseases, but how citrullinated vimentin is associated with disease prevalence and genetic variants in a clinical setting remains unknown.
Cecilie Liv Bager +8 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Despite the overall clinical success of immune checkpoint inhibitors (ICIs) for treating patients with solid tumors, a large number of patients do not benefit from this approach. Consequently, there is a need for predictive biomarkers. The most prevalent
Christina Jensen +4 more
doaj +1 more source
Intermittent Dynamic Compression Confers Anabolic Effects in Articular Cartilage
Applied Sciences, 2021 (1) Background: Mechanical loading is an essential part of the function and maintenance of the joint. Despite the importance of intermittent mechanical loading, this factor is rarely considered in preclinical models of cartilage, limiting their ...
Amalie Engstrøm +6 more
doaj +1 more source
Scientific Reports, 2021 Osteoarthritis (OA) and rheumatoid arthritis (RA) are serious and painful diseases. Protease-activated receptor 2 (PAR2) is involved in the pathology of both OA and RA including roles in synovial hyperplasia, cartilage destruction, osteophyogenesis and ...
Stefania Kalogera +7 more
doaj +1 more source
Lot-to-Lot Variance in Immunoassays—Causes, Consequences, and Solutions
Diagnostics, 2023 Immunoassays, which have gained popularity in clinical practice and modern biomedical research, play an increasingly important role in quantifying various analytes in biological samples.
Yunyun Luo +5 more
doaj +1 more source
NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein
Scientific Reports, 2023 NTSR1 abnormal expression by cancer cells makes it a strategic target for antitumoral therapies, such as compounds that use NTSR1 binding probes to deliver cytotoxic agents to tumor cells.
Fotine Libanje +6 more
doaj +1 more source
Environmental risk factors and their footprints in vivo – a proposal for the classification of oxidative stress biomarkers [PDF]
, 2020 Environmental agents, including socioeconomic condition, and host factors can act as causal agents and risk factors in disease. We use biomarkers and sociomarkers to study causal factors, such as overproduction of reactive oxygen species (ROS) which ...
Ghezzi, Pietro
core +1 more source
Biomarker Research, 2023 Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating.
Miranda Burdiel +17 more
doaj +1 more source