Results 1 to 10 of about 2,936,789 (384)

Biomarkers in sepsis. [PDF]

open access: yesCurrent Infectious Disease Reports, 2013
Purpose of review: This review discusses the current developments in biomarkers for sepsis. Recent findings: With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely ...
Singer, M
core   +3 more sources

The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile

open access: yesBMC Endocrine Disorders, 2021
Background Weight loss therapy is becoming more and more important, and two classes of molecules, namely amylin receptor and GLP-1 receptor agonists, have shown promise in this regard.
Anna Thorsø Larsen   +4 more
doaj   +1 more source

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting [PDF]

open access: yes, 2019
The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed ...
Blair, Ian A.   +8 more
core   +1 more source

Biomarkers in emergency medicine [PDF]

open access: yes, 2018
Researchers navigate the ocean of biomarkers searching for proper targets and optimal utilization of them. Emergency medicine builds up the front line to maximize the utility of clinically validated biomarkers and is the cutting edge field to test the ...
Cardelli, P., Hur, M., Somma, S. D.
core   +2 more sources

Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

open access: yesBiomarker Research, 2023
Background Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their association with immune checkpoint ...
Dingwei Ye   +16 more
doaj   +1 more source

Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

open access: yes, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Ahsen, Nico von   +7 more
core   +1 more source

Integration of Proteomics, Bioinformatics and Systems biology in Brain Injury Biomarker Discovery

open access: yesFrontiers in Neurology, 2013
Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes.
Joy eGuingab-Cagmat   +3 more
doaj   +1 more source

Conditional Screening for Ultra-high Dimensional Covariates with Survival Outcomes [PDF]

open access: yes, 2016
Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine.
Hong, Hyokyoung Grace   +2 more
core   +3 more sources

The potential of pathological protein fragmentation in blood-based biomarker development for dementia – with emphasis on Alzheimer’s disease

open access: yesFrontiers in Neurology, 2015
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early interven-tion. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the
Dilek eInekci   +4 more
doaj   +1 more source

Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions

open access: yesAntioxidants, 2021
Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics.
Pedro Ayuso   +2 more
doaj   +1 more source

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