Results 31 to 40 of about 2,058,753 (356)

The potential of pathological protein fragmentation in blood-based biomarker development for dementia – with emphasis on Alzheimer’s disease

Frontiers in Neurology, 2015
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early interven-tion. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the
Dilek eInekci, Ditte Svendsen Jonesco, Sophie eKennard, Morten Asser Karsdal, Kim eHenriksen   +4 more
doaj   +1 more source

Precision medicine for suicidality: from universality to subtypes and personalization [PDF]

, 2017
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders.
Ballew, A, Dainton, H L, Gelbart, T, Graham, D L, Jones, T J, Kurian, S M, Le-Niculescu, H, Levey, D F, Niculescu, A B, Niculescu, E M, Niezer, J O, Phalen, P L, Roseberry, K, Salomon, D R, Sandusky, G E, Schork, N J, Shekhar, A, Venugopal, V, Williams, A, Yard, M   +19 more
core   +1 more source

Predicting Suicidal Behavior: Are We Really that Far Along? Comment on “Discovery and Validation of Blood Biomarkers for Suicidality” [PDF]

, 2013
A recent publication focused on biomarkers of future suicidal behaviors identifies several genes expressed in high-risk states among four samples. We discuss the implications of this study as well as the current state of research regarding biomarkers of ...
Baca-García, Enrique, Blasco-Fontecilla, Hilario, Giner Jiménez, Lucas, Lopez Castroman, Jorge, Oquendo, María   +4 more
core   +1 more source

Biomarkers in respiratory diseases [PDF]

, 2012
The scientific evidence concerning prosthodontic care for the shortened dental arch (SDA) is sparse. This randomized multicenter study aimed to compare two common treatment options: removable partial dental prostheses (RPDPs) for molar replacement vs ...
Busche, E., Gernet, W., Hannak, W., Hartmann, S., Heydecke, Guido, Huppertz, J., Kern, Matthias, Luthardt, R. G., Marré, B., Mitov, G., Mundt, T., Passia, N., Pospiech, P., Reiber, T., Reinhardt, W., Stark, H., Walter, M. H., Weber, A., Wolfart, Stefan, Wöstmann, B.   +19 more
core   +2 more sources

Conditional Screening for Ultra-high Dimensional Covariates with Survival Outcomes [PDF]

, 2016
Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine.
Hong, Hyokyoung Grace, Kang, Jian, Li, Yi   +2 more
core   +3 more sources

Biomarkes of aging

Frontiers in Bioscience, 2010
Ageing is a complex process that negatively impacts the development of the different systems and its ability to function. On the other hand, the rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors.
Vasto S., Scapagnini G., Bulati M., Candore G., Castiglia L., Colonna Romano G., Lio D., Nuzzo D., Pellicano M., Rizzo C., FERRARA, NICOLA, Caruso C.   +11 more
openaire   +6 more sources

Biomarkers of apoptosis [PDF]

British Journal of Cancer, 2008
Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H., Cummings, J., Dean, E., Greystoke, A., Hou, J. M., Backen, A., Ranson, M., Dive, C.   +7 more
openaire   +4 more sources

Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Ahsen, Nico von, Krack, Lennart, Kretzschmar, Hans, Meissner, Bettina, Redyk, Katharina, Roeber, Sigrun, Schmidt, Christian, Zerr, Inga   +7 more
core   +1 more source

Characterization of Antibodies that Detect Human GFAP after Traumatic Brain Injury

Biomarker Insights, 2012
After traumatic brain injury (TBI), glial fibrillary acidic protein (GFAP) and other brain-derived proteins and their breakdown products are released into biofluids such as CSF and blood.
J. Susie Zoltewicz, Dancia Scharf, Boxuan Yang, Aarti Chawla, Kimberly J. Newsom, Lijuan Fang   +5 more
doaj   +1 more source

Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics [PDF]

, 2012
Background: Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a ...
AA Elgamal, B Brügger, BR Pflug, CG Rogers, Charles Pound, Christina Lynn Addison, D Pchejetski, EF Petricoin, F Bravi, F Teichert, FL Crowe, G Balogh, G Draisma, G Liebisch, H He, HK Min, IM Thompson, IM Thompson, J Ding, J Graessler, J Graessler, J Kurhanewicz, Jeffrey Henegar, Jinghe Mao, JR Graff, Junmei Ai, K Athenstaedt, K Ekroos, K Simons, KA Landers, KH Pietiläinen, KR Keshari, L Zhuang, M Kolak, M Lankinen, M Ollero, Mary R. Roth, MG Swanson, ML Ramírez, O Quehenberger, R Bartz, R Etzioni, R Görke, R Welti, RJ Hamilton, RS Kirby, Ruth Welti, S Devaiah, Steven A. Bigler, TC Gibbs, VD de Mello, VL Freeman, X Han, X Han, X Zhou, Xinchun Zhou, Y Xie, Y Zeng, Youping Deng   +58 more
core   +4 more sources