Results 41 to 50 of about 2,058,753 (356)

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss [PDF]

, 2016
Background: A hypothesis exists whereby an exercise- or dietary-induced negative energy balance reduces human subcutaneous white adipose tissue (scWAT) mass through the formation of brown-like adipocyte (brite) cells.
Andrea R Josse, Asif Nakhuda, Björntorp, Chamorro-García, Collins, Crawford, Cypess, de Jong, Després, Digby, Donzelli, Ellero-Simatos, Frederic Raymond, Gburcik, Gburcik, Hannah Crossland, Holmström, James A Timmons, Jespersen, Josse, Josse, Krämer, Kusu, Lee, Liam Good, Lind, Moulin, Nissen, Petrovic, Petrovic, Philip J Atherton, Seale, Seale, Shan, Sood, Stanford, Stanford, Stenson, Stuart M Phillips, Sylviane Metairon, Timmons, Timmons, Timmons, Timmons, Toseland, Valentina Gburcik, Waldén, Wang, Wu   +48 more
core   +2 more sources

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

Arthritis Research & Therapy, 2019
Background Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease ...
Anna Katri, Aneta Dąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium, Kim Henriksen   +7 more
doaj   +1 more source

Biomarkers: a strategic tool in the assessment of environmental quality of coastal waters [PDF]

, 2007
Ecosystems are under the pressure of complex mixtures of contaminants whose effects are not always simple to assess. Biomarkers, acting as early warning signals of the presence of potentially toxic xenobiotics, are useful tools for assessing either ...
Bebianno, Maria João, Costa, M. H., Ferreira, A., Picado, Ana, Vale, C.   +4 more
core   +1 more source

Serum micrornas as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma [PDF]

, 2016
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and specific biomarkers, as is the early diagnosis of cholangiocarcinoma (CC), a complication of PSC.
Alpini, Gianfranco, Alvaro, Domenico, Bernuzzi, Francesca, Bowlus, Christopher L, Carbone, Marco, Eric Gershwin, M, He, Xiao Song, Invernizzi, Pietro, Lleo, Ana, Locati, Massimo, Marabita, Francesco, Marzioni, Marco, Mirolo, Massimiliano, Muri Boberg, Kirsten, Piscaglia, Fabio, Rimassa, Lorenza, Torzilli, Guido, Yang, Guo Xiang   +17 more
core   +2 more sources

Epilepsy biomarkers [PDF]

Epilepsia, 2013
SummaryA biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the ...
Pitkänen, Asla, Loeb, Jeffrey, Dudek, F, Bertram, Edward, Cole, Andrew, Moshé, Solomon, Wiebe, Samuel, Jensen, Frances, Mody, Istvan, Nehlig, Astrid, Vezzani, Annamaria, Engel, Jerome   +11 more
openaire   +6 more sources

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Journal of Experimental & Clinical Cancer Research, 2019
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal ...
Neel I. Nissen, Morten Karsdal, Nicholas Willumsen   +2 more
doaj   +1 more source

Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

Respiratory Research, 2021
Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function and a high mortality rate.
H. Jessen, N. Hoyer, T. S. Prior, P. Frederiksen, M. A. Karsdal, D. J. Leeming, E. Bendstrup, J. M. B. Sand, S. B. Shaker   +8 more
doaj   +1 more source

ST2 and Multimarker Testing in Acute Decompensated Heart Failure [PDF]

, 2015
Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge.
Antoni, Md, Bayes, Genis, DI SOMMA, Salvatore, Maisel, Alan S., Md,, Md,, Md,, Mebazaa, Alexandre   +7 more
core   +1 more source

Assessment of treatment response in tuberculosis [PDF]

, 2016
Antibiotic treatment of tuberculosis has a duration of several months. There is significant variability of the host immune response and the pharmacokinetic-pharmacodynamic properties of Mycobacterium tuberculosis sub-populations at the site of disease. A
Du Bruyn, E, Morris, T, Rockwood, N, Wilkinson, RJ   +3 more
core   +1 more source

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

Journal of Experimental & Clinical Cancer Research, 2022
Background Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase for mitochondrial fission, Drp1 is frequently upregulated in many cancers and is closely implicated in ...
Yujia Li, Hui Chen, Qi Yang, Lixin Wan, Jing Zhao, Yuanyuan Wu, Jiaxin Wang, Yating Yang, Menglan Niu, Hongliang Liu, Junqi Liu, Hushan Yang, Shaogui Wan, Yanming Wang, Dengke Bao   +14 more
doaj   +1 more source