Results 51 to 60 of about 2,487,880 (329)
Journal of Stroke, 2013 Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other body fluids or tissues that predicts physiologic or disease states, increased disease risk, or pharmacologic responses to a therapeutic intervention.
Suk Jae Kim +2 more
openaire +3 more sources
Diagnostics, 2023 Sepsis is a highly complex disease caused by a deregulated host’s response to infection [...]
Luisa Agnello, Marcello Ciaccio
openaire +4 more sources
The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer. [PDF]
, 2014 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures ...
Haisheng eXu +4 more
core +2 more sources
Frontiers in Bioscience, 2010 Ageing is a complex process that negatively impacts the development of the different systems and its ability to function. On the other hand, the rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors.
Vasto S. +11 more
openaire +6 more sources
Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]
, 2010 Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Ahsen, Nico von +7 more
core +1 more source
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
Science, 2018 Mining immunotherapy clinical trials Clinical trial data can provide a wealth of information about how drugs work. Yet such information often belongs to pharmaceutical companies and is rarely accessible to the scientific community at large.
R. Cristescu +23 more
semanticscholar +1 more source
Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics [PDF]
, 2012 Background: Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a ...
AA Elgamal +58 more
core +3 more sources
British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
openaire +4 more sources
Characterization of Antibodies that Detect Human GFAP after Traumatic Brain Injury
Biomarker Insights, 2012 After traumatic brain injury (TBI), glial fibrillary acidic protein (GFAP) and other brain-derived proteins and their breakdown products are released into biofluids such as CSF and blood.
J. Susie Zoltewicz +5 more
doaj +1 more source
Bayesian meta-analysis for evaluating treatment effectiveness in biomarker subgroups using trials of mixed patient populations [PDF]
arXiv, 2023 During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enrol biomarker-positive patients alone, thus leading to trials of the same treatment investigated in different populations.
arxiv