Results 51 to 60 of about 2,058,753 (356)

Cancer biomarker development from basic science to clinical practice [PDF]

, 2018
The amount of published literature on biomarkers has exponentially increased over the last two decades. Cancer biomarkers are molecules that are either part of tumour cells or secreted by tumour cells.
Ali, Asif, Ali, Zafar, Oien, Karin A., Yousafzai, Yasar Mehmood   +3 more
core  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Comparative metabolomic profiling of women undergoing in vitro fertilization procedures reveals potential infertility-related biomarkers in follicular fluid

Scientific Reports, 2022
Infertility is a worldwide concern, affecting one in six couples throughout their reproductive period. Therefore, enhancing the clinical tools available to identify the causes of infertility may save time, money, and emotional distress for the involved ...
Mohamed Ziad Dabaja, Aline Amaro dos Santos, Denise Maria Christofolini, Caio Parente Barbosa, Diogo Noin de Oliveira, Arthur Noin de Oliveira, Carlos Fernando Odir Rodrigues Melo, Tatiane Melina Guerreiro, Rodrigo Ramos Catharino   +8 more
doaj   +1 more source

Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]

, 2016
Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro, Mischak, Harald, Zürbig, Petra   +2 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

Journal of Pharmaceutical Analysis, 2022
Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers.
Kevin McKinski, Dean McNulty, Francesca Zappacosta, Mary Birchler, Matt Szapacs, Christopher Evans   +5 more
doaj  

Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Triple-negative breast cancer (TNBC) corresponds to approximately 20% of all breast tumors, with a high propensity for metastasis and a poor prognosis.
Jun Wang, Peng Liu, Nicholas Lemoine, Yaohe Wang, Louisa S Chard Dunmall, Carmela Di Gioia, Claude Chelala, Renato Brito Baleeiro, Ai Nagano, Lauren Cutmore, Lydon Wainaina Nyambura, Peter Walden   +11 more
doaj   +1 more source

Identification of suitable biomarkers for stress and emotion detection for future personal affective wearable sensors [PDF]

, 2020
Skin conductivity (i.e., sweat) forms the basis of many physiology-based emotion and stress detection systems. However, such systems typically do not detect the biomarkers present in sweat, and thus do not take advantage of the biological information in ...
Andrews, Simon, Dey, Nilanjan, Hui, Terence, Sherratt, R. Simon, Shi, Fuqian, Zamkah, Abdulaziz   +5 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Biomarkers in psychiatry [PDF]

Nature, 2009
The use of biomarkers to predict human behaviour and psychiatric disorders raises social and ethical issues, which must be resolved by collaborative efforts.
Singh, Ilina, Rose, Nikolas
openaire   +3 more sources