Results 71 to 80 of about 1,320,970 (304)

Destruction energy index (DEI) of vitamin E blended UHMWPE for artificial joints

Biosurface and Biotribology, 2019
Destruction resistance such as start-up wear resistance characteristics of vitamin E (dl-α-tocopherol) blended ultra-high molecular weight polyethylene (UHMWPE) were evaluated using the destruction energy index (DEI).
Naoya Hatano, Masaya Higaki, Masaya Higaki, Youhei Otsu, Tatsuya Otsu, Shinji Mikami, Mitsuhiro Matsumoto, Daisuke Kono, Atsushi Matsubara, Naohide Tomita   +9 more
doaj   +1 more source

Biomedicals from Bone [PDF]

, 2008
The realm of biomaterials, under which biomedical materials can be categorised, has a broad definition base and recognises materials that are synthesized or naturally sourced.
Mucalo, Michael R., Worth, Andrew J.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Enhanced antibacterial activity and superior biocompatibility of cobalt-deposited titanium discs for possible use in implant dentistry

iScience
Summary: The clinical success of implants depends on rapid osseointegration, and new materials are being developed considering the increasing demand. Considering cobalt (Co) antibacterial characteristics, we developed Co-deposited titanium (Ti) using ...
Vaibhav Madiwal, Bhushan Khairnar, Jyutika Rajwade   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats

IET Nanobiotechnology, 2021
Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ ...
Ragavee Ambalavanan, Arul Daniel John, Asha Devi Selvaraj   +2 more
doaj   +1 more source

Horn-like space-coiling metamaterials toward simultaneous phase and amplitude modulation [PDF]

, 2018
Acoustic metasurfaces represent a family of planar wavefront-shaping devices garnering increasing attention due to their capacity for novel acoustic wave manipulation.
Anderson, Stephan, Ghaffarivardavagh, Reza, Holt, R. Glynn, Nikolajczyk, Jacob, Zhang, Xin   +4 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Seawater-contaminated ulnar rabbit bone defects repair using 3D-printed β-TCP/vancomycin composite scaffolds

European Cells & Materials
Background: Repairing extensive bone defects following seawater immersion poses a significant challenge for orthopedic surgeons. Recent advancements in three-dimensional (3D) printing technology have demonstrated considerable potential in fabricating ...
HD Lao, D Liu, R Yi, YN Yuan, M Zhao, GS Li, XY Nie, JL Gu, XM Cai, H Li, SE Lin, JJ Zhou   +11 more
doaj   +1 more source

Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin‐induced type 1 diabetes in rats

IET Nanobiotechnology, 2021
This study examines the effect of nanoparticles with zinc oxides (ZnONPs) on diabetic nephropathy, which is the primary cause of mortality for diabetic patients with end‐stage renal disease.
Ghada Alomari, Bahaa Al‐Trad, Salehhuddin Hamdan, Alaa A. A. Aljabali, Mazhar Salim Al Zoubi, Khalid Al‐Batanyeh, Janti Qar, Gregory J. Eaton, Almuthanna K. Alkaraki, Walhan Alshaer, Saja Haifawi, Khairunadwa Jemon, Dinesh Kumar Chellappan, Kamal Dua, Murtaza M. Tambuwala   +14 more
doaj   +1 more source