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Bioorthogonal chemistry in bioluminescence imaging
Drug Discovery Today, 2018Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of ...
Aurélien Godinat +2 more
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Finding the Right (Bioorthogonal) Chemistry
ACS Chemical Biology, 2014Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and other complex environments. With over 20 unique transformations now available, though, selecting an appropriate reaction for a given experiment is challenging.
David M, Patterson +2 more
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Pretargeted imaging using bioorthogonal chemistry in mice
Current Opinion in Chemical Biology, 2014Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged ...
Raffaella, Rossin, Marc S, Robillard
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Bioorthogonal Chemistry—Introduction and Overview
Topics in Current Chemistry, 2016Bioorthogonal chemistry has emerged as a new powerful tool that facilitates the study of structure and function of biomolecules in their native environment. A wide variety of bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions are now available.
Thomas Carell, Milan Vrabel
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The Unique Bioorthogonal Chemistry of Isonitriles
Synlett, 2020The isocyano group is the structurally most compact bioorthogonal group known. It reacts with tetrazines under physiological conditions and has great potential for widespread use in the biosciences. In this account, we highlight the unique properties of the isocyano group as a bioorthogonal functionality.
Raphael M. Franzini, Titas Deb
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Bioorthogonal chemistry for prodrug activation in vivo
Chemical Society Reviews, 2023Bioorthogonal chemistry used in prodrug activation for cancer treatment and its potential for clinical translation.
Qunfeng Fu +6 more
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Intracellular bioorthogonal chemistry
2018Bioorthogonal reactions have a central role in medicinal therapeutics and diagnostics. Extracellularly binding substances, like antibodies, are often used as targeting agents and are coupled with a bioorthogonal reaction agent. The most popular combination nowadays is the inverse electron demand Diels-Alder reaction between a trans-cyclooctene and a ...
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Cycloadditions in Bioorthogonal Chemistry
2016The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.
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Seeing small molecules in action with bioorthogonal chemistry
Drug Discovery Today, 2009Chemical probes that target specific protein families offer powerful tools to accelerate drug discovery. Small molecules modified with uniquely reactive functional groups and detection tags provide novel tools to characterize complex proteomes functionally and also to help determine the specificity of small molecule inhibitors toward various enzyme ...
Anuradha S, Raghavan, Howard C, Hang
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Bioorthogonal chemistry for biological insights
Cell Chemical BiologyContinuing the celebration of Cell Chemical Biology's 30th anniversary, this focus issue presents the spectrum of ways that bioorthogonal chemistry empowers biological and biomedical studies. The following opinion pieces, reviews, and research articles highlight specific approaches and insights that are key to addressing biological questions.
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