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Voices: Challenges and opportunities for bioorthogonal chemistry
Cell Chemical BiologyBioorthogonal chemistry was deservedly recognized with the 2022 Nobel Prize in Chemistry, having transformed the way chemists and biologists interrogate biological systems in the past twenty years. This Voices piece asks researchers from a range of backgrounds: what are some major challenges and opportunities facing the field in coming years?
Ku-Lung, Hsu +4 more
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Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
Accounts of Chemical Research, 2011The close interaction between organic chemistry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds, thereby contributing to the understanding of ...
Lianne I, Willems +8 more
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3 Strain-Promoted Bioorthogonal Chemistry
AbstractStrain-promoted bioorthogonal reactions, driven by cycloalkynes and cycloalkenes, have become indispensable in chemical biology. These strained chemical tools enable selective bioorthogonal ligations and bond-cleavage reactions, supporting research and development in various emerging fields such as molecular imaging, targeted drug delivery, andN. Pfleger, A. Schiefer, H. Mikula
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Bioorthogonal chemistry-driven anticancer nanotherapeutics
Trends in Chemistry, 2023Hongyuan Zhang +4 more
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Machine learning in combinatorial polymer chemistry
Nature Reviews Materials, 2021Adam J Gormley, Michael A Webb
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12 Bioorthogonal Chemistry of Nucleic Acids
AbstractBioorthogonal chemistry is a powerful tool allowing the modification of DNA and RNA through incorporation of artificial reactive groups that can function in a live environment, without interfering with natural biological processes. This chapter reviews the main strategies for installing bioorthogonal functionalities into nucleic acid ...R. M. R. M. Lopes +7 more
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Chemistry and materials science for a sustainable circular polymeric economy
Nature Reviews Materials, 2022Vânia G Zuin, Klaus Kümmerer
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Bioorthogonal Chemistry—Introduction and Overview [corrected].
Topics in current chemistry (Cham), 2019Bioorthogonal chemistry has emerged as a new powerful tool that facilitates the study of structure and function of biomolecules in their native environment. A wide variety of bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions are now available.
Thomas, Carell, Milan, Vrabel
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Recent advances in the chemistry and applications of N-heterocyclic carbenes
Nature Reviews Chemistry, 2021Peter Bellotti +2 more
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