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Development of Bioorthogonal Reactions and Their Applications in Bioconjugation [PDF]
Molecules, 2015 Biomolecule labeling using chemical probes with specific biological activities has played important roles for the elucidation of complicated biological processes. Selective bioconjugation strategies are highly-demanded in the construction of various small-molecule probes to explore complex biological systems.
Jinbo Li, Peiyuan Zhang, Mengmeng Zheng
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Advances of Bioorthogonal Coupling Reactions in Drug Development
European Journal of Medicinal Chemistry, 2023Currently, bioorthogonal coupling reactions have garnered considerable interest due to their high substrate selectivity and less restrictive reaction conditions. During recent decades, bioorthogonal coupling reactions have emerged as powerful tools in drug development.
Jinyi Xu, Shengtao Xu, Shaowen Xie
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Mechanisms and Substituent Effects of Metal-Free Bioorthogonal Reactions
Chemical Reviews, 2021Reactions that occur under physiological conditions find diverse uses in the chemical and biological sciences. However, the limitations that biological systems place on chemical reactions restrict the number of such bioorthogonal reactions. A profound understanding of the mechanistic principles and structure-reactivity trends of these transformations ...
Raphael M Franzini, Titas Deb, Julian Tu
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Bioorthogonal Click and Release Reaction of Iminosydnones With Cycloalkynes
Angewandte Chemie - International Edition, 2017AbstractWe report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for
Frédéric Taran +2 more
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Building better bioorthogonal reactions
Current Opinion in Chemical Biology, 2014Over the past two decades, there has been intense interest in designing and implementing selective (bioorthogonal) reactions for biomolecule tracking. Here we review the most widely used bioorthogonal chemistries in live cells and animals, drawing particular attention to the unique functional groups underlying these transformations.
Hui-Wen, Shih +2 more
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Photo-activatable Reagents for Bioorthogonal Ligation Reactions
Topics in Current Chemistry, 2023Light-induced bioorthogonal reactions offer spatiotemporal control over selective biomolecular labeling. This review covers the recent advances in the design of photo-activatable reagents for bioorthogonal conjugation reactions in living systems.
Heyang, Zhang, Ming, Fang, Qing, Lin
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Bioorthogonal Reactions for Labeling Proteins
ACS Chemical Biology, 2014O the past 15 years a great deal of progress has been made on the discovery, rediscovery, and invention of bioorthogonal reactions between functional groups that do not react with biological entities under physiological conditions but selectively react with each other.
Kathrin, Lang, Jason W, Chin
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In Vivo Applications of Bioorthogonal Reactions: Chemistry and Targeting Mechanisms
Chemistry - A European Journal, 2023 AbstractBioorthogonal chemistry involves selective biocompatible reactions between functional groups that are not normally present in biology. It has been used to probe biomolecules in living systems, and has advanced biomedical strategies such as diagnostics and therapeutics.
Helen Osborn
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Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions
Topics in Current Chemistry, 2015In recent years, bioorthogonal reactions have emerged as a powerful toolbox for specific labeling and visualization of biomolecules, even within the highly complex and fragile living systems. Among them, copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is one of the most widely studied and used biocompatible reactions.
Maiyun, Yang, Yi, Yang, Peng R, Chen
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Turning on bioorthogonal reactions catalytically
C&EN Global Enterprise, 2016To attach probes for imaging to biomolecules inside cells or organisms, chemists have developed so-called bioorthogonal reactions that don’t interfere with the biochemistry of the living things. Tetrazine ligation is the fastest of these bioorthogonal reactions, and its speed allows scientists to use small amounts of reagents to get the job done. A new
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