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Bioorthogonal Reactions for Labeling Proteins
ACS Chemical Biology, 2014O the past 15 years a great deal of progress has been made on the discovery, rediscovery, and invention of bioorthogonal reactions between functional groups that do not react with biological entities under physiological conditions but selectively react with each other.
Kathrin, Lang, Jason W, Chin
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Bridgehead Alkene-Enabled Strain-Driven Bioorthogonal Reaction
Organic Letters, 2022Herein, we report a novel bioorthogonal reaction that hinges on a bridgehead alkene (BHA)-enabled inverse-electron-demand Diels-Alder (IEDDA) cycloaddition. Readily accessible from natural product β-caryophyllene, the strained BHA displays high reactivity toward the IEDDA reaction while maintaining excellent biocompatibility.
Fayang Xie +6 more
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Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions
Topics in Current Chemistry, 2015In recent years, bioorthogonal reactions have emerged as a powerful toolbox for specific labeling and visualization of biomolecules, even within the highly complex and fragile living systems. Among them, copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is one of the most widely studied and used biocompatible reactions.
Maiyun, Yang, Yi, Yang, Peng R, Chen
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Advances of bioorthogonal coupling reactions in drug development
European Journal of Medicinal Chemistry, 2023Currently, bioorthogonal coupling reactions have garnered considerable interest due to their high substrate selectivity and less restrictive reaction conditions. During recent decades, bioorthogonal coupling reactions have emerged as powerful tools in drug development.
Feiyan Zhan +4 more
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Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions
Topics in Current Chemistry, 2015Bioorthogonal reactions have been widely used over the last 10 years for imaging, detection, diagnostics, drug delivery, and biomaterials. Tetrazine reactions are a recently developed class of inverse electron-demand Diels-Alder reactions used in bioorthogonal applications.
Haoxing, Wu, Neal K, Devaraj
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Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications
Angewandte Chemie, 2023AbstractBioorthogonal chemistry is a promising toolbox for dissecting biological processes in the native environment. Recently, bioorthogonal reactions have attracted considerable attention in the medical field for treating diseases, since this approach may lead to improved drug efficacy and reduced side effects via in situ drug synthesis.
Zhengwei Liu +4 more
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Optimized aqueous Kinugasa reactions for bioorthogonal chemistry applications
Chemical Communications, 2020We present optimized micelle-assisted aqueous copper(i)-catalyzed alkyne–nitrone cycloaddition involving rearrangement (CuANCR) reactions applicable to bioorthogonal applications, namely membrane-associated peptide modification.
Didier A. Bilodeau +5 more
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Recent Developments and Strategies for Mutually Orthogonal Bioorthogonal Reactions
ChemBioChem, 2021AbstractOver the past decade, several different metal‐free bioorthogonal reactions have been developed to enable simultaneous double‐click labeling with minimal‐to‐no competing cross‐reactivities; such transformations are termed ‘mutually orthogonal’. More recently, several examples of successful triple ligation strategies have also been described.
Yun Hu, Jennifer M. Schomaker
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Turning on bioorthogonal reactions catalytically
C&EN Global Enterprise, 2016To attach probes for imaging to biomolecules inside cells or organisms, chemists have developed so-called bioorthogonal reactions that don’t interfere with the biochemistry of the living things. Tetrazine ligation is the fastest of these bioorthogonal reactions, and its speed allows scientists to use small amounts of reagents to get the job done. A new
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Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions
Chemical Society Reviews, 2020This review assesses the mechanistic aspects of transition metal-mediated uncaging reactions, with the goal of aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
Eloah Latocheski +5 more
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